摘要
目的:了解湿性年龄相关性黄斑变性(wAMD)患者抗血管内皮生长因子(VEGF)治疗的视力预后,评估影响视力预后的相关因素。方法:回顾性研究行抗VEGF治疗的wAMD患者44例54眼的资料,统计患者年龄、性别、发病眼别、初始视力、治疗前的光学相干断层扫描(OCT)图像特征以及注药次数,探讨影响视力预后的相关因素。结果:治疗后视网膜下液(SRF)、视网膜间液(IRF)面积均小于术前(P<0.01),治疗后黄斑中心凹厚度(CMT)低于术前(P<0.001);wAMD患者视力预后(LogMar视力)与患者年龄(P=0.004)、治疗前初始最佳矫正视力(BCVA)(P<0.001)、IRF以及IRF面积(P=0.009;P=0.011)、视网膜下高反射物质(SHRM)(P=0.019)、脉络膜新生血管(CNV)最大高度及CNV直径(P=0.012;P=0.001)均呈正相关,而与患者性别、发病眼别、SRF及其面积、CMT相关性无统计学意义。结论:抗VEGF治疗可有效改善患者黄斑区水肿情况;年龄越大、初始视力越差、初次OCT检查中IRF越多、存在SHRM、CNV越大提示wAMD患者的视力预后越差。
Objective:To observe the visual acuity outcome in patients with wet age-related macular degeneration(wAMD)following therapy with antagonists of vascular endothelial growth factor(anti-VEGF)by intravitreal injection,and evaluate the factors affecting prognosis of the visual acuity.Methods:Retrospective study was performed in 44 wAMD patients(54 eyes)undergone intravitreal anti-VEGF therapy.The indicators,including the patient′s age,gender,laterality,initial best corrected visual acuity(BCVA),optical coherence tomography(OCT)image property,and the number of injections were statistically summed up for exploring the relevant factors affecting visual acuity outcome.Results:After intravitreal anti-VEGF therapy,the fovea thickness,and the area of subretinal fluid(SRF)and intraretinaI fluid(IRF)were significantly smaller compared with those before treatment(all P<0.01).The visual acuity outcome(LogMAR)was positively correlated with the age(P=0.004),initial LogMAR visual acuity(P<0.001),presence of intraretinaI fluid(IRF)(P=0.009)and IRF area(P=0.011)as well as subretinal hyperreflective materials(SHRM)(P=0.010),maximum height of choroidal neovascularization(CNV)(P=0.012)and CNV diameter(P=0.001),yet was not related to the gender,laterality,presence of SRF and central macular thickness(CMT).Conclusion:Intravitreal anti-VEGF therapy can effectively reduce macular edema in patients with wAMD.Older age,worse initial visual acuity,more IRF,presence of SHRM,and larger CNV suggest worse visual outcomes in wAMD patients after intravitreal anti-VEGF injection.
作者
杨宇
董继红
张荣荣
黄宝玲
刘银萍
梅立新
吴昌凡
YANG Yu;DONG Jihong;ZHANG Rongrong;HUANG Baoling;LIU Yinping;MEI Lixin;WU Changfan(Department of Ophthalmology,The First Affiliated Hospital of Wannan Medical College,Wuhu 241001,China)
出处
《皖南医学院学报》
CAS
2022年第1期36-39,共4页
Journal of Wannan Medical College
基金
安徽省卫生健康委科研项目(AHWJ2021b120)。
