摘要
目的探讨女性人乳头瘤病毒(HPV)感染亚型分布合并支原体感染及与宫颈癌和癌前病变的关系。方法选择2019年5月—2021年5月行妇科检查的218例为研究对象,依据检查结果分为宫颈癌组(n=102)、宫颈高级别上皮内瘤变(HSIL)组(n=61)、宫颈低级别上皮内瘤变(LSIL)组(n=55)。检测3组HPV感染亚型分布情况及支原体感染情况,比较不同宫颈病变患者总HPV感染率、持续HPV感染率和支原体感染率,分析宫颈支原体感染与HPV感染的相关性,并明确支原体感染在不同HPV感染状态下与宫颈病变的关系。结果宫颈癌组检出14种HPV分型,HPV16检出率最高,其次为HPV18、HPV58;宫颈HSIL组检出HPV分型13种,HPV16检出率最高,HPV52、HPV58检出率次之;宫颈LSIL组检出8种HPV分型,前三位分型分别为HPV16、HPV52、HPV31。宫颈癌组总HPV感染率、持续HPV感染率高于宫颈HSIL组、宫颈LSIL组(P<0.05,P<0.01)。持续HPV感染阳性者支原体感染率高于阴性者(P<0.05)。持续HPV阳性且支原体阳性者宫颈癌占比高于宫颈HSIL组、宫颈LSIL组(P<0.05)。结论支原体感染可明显增加持续HPV感染的风险,且是持续HPV感染导致宫颈癌发生的协同感染因素,积极监测宫颈病变患者HPV和支原体感染情况对宫颈癌防治有一定指导意义。
Objective To investigate distribution of human papillomavirus(HPV)infection subtypes and mycoplasma infection status in females,and their correlations with the occurrence of cervical cancer and precancerous lesions.Methods A total of 218 women with cervical diseases who had undergone gynecological examinations between May 2019 and May 2021 were selected as research subjects.According to examination results,the women were divided into cervical cancer group(n=102),cervical high-grade intraepithelial neoplasia(HSIL)group(n=61)and cervical low-grade intraepithelial neoplasia(LSIL)group(n=55).Distribution condition of HPV infection subtypes and mycoplasma infection status were detected in each group.The total HPV infection rate,continued HPV infection rate and mycoplasma infection rate in patients with different cervical lesions were compared.The correlation between cervical mycoplasma infection and HPV infection was analyzed.Correlations between mycoplasma infection with cervical lesions under different HPV infection status were clarified.Results In cervical cancer group,14 HPV types were detected,and the detection rate of HPV16 was the highest,followed by HPV18 and HPV58.In HSIL group,13 HPV types were detected,and the detection rate of HPV16 was the highest,followed by HPV52 and HPV58.In LSIL group,8 HPV types were detected,and the top three types were HPV16,HPV52 and HPV31.The total HPV infection rate and continued HPV infection rate in cervical cancer group were significantly higher than those in HSIL and LSIL groups(P<0.05,P<0.01).The mycoplasma infection rate in patients with continued HPV positive infection was significantly higher than that in patients with HPV negative infection(P<0.05).The rate of cervical cancer was significantly higher than rates of HSIL and LSIL groups in continued HPV-positive and mycoplasma-positive patients with cervical cancer(P<0.05).Conclusion Mycoplasma infection significantly increases the risk of continued HPV infection,and mycoplasma infection is a co-infection factor of continued HPV infection leading to the occurrence of cervical cancer.Active monitoring of HPV infection and mycoplasma infection in patients with cervical lesions is of guiding significance for prevention and treatment of cervical cancer.
作者
李媛媛
嵇玉蓉
马海英
LI Yuan-yuan;JI Yu-rong;MA Hai-ying(Department of Cervical Diseases,Subei People's Hospital,Yangzhou,Jiangsu 225001,China;Department of Reproductive Center,Subei People's Hospital,Yangzhou,Jiangsu 225001,China;Department of Obstetrics and Gynecology,the Second People's Hospital of Yangzhou City,Yangzhou,Jiangsu 225001,China)
出处
《解放军医药杂志》
CAS
2022年第2期48-52,共5页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
江苏省卫生计生委面上项目(H201935)。
关键词
宫颈肿瘤
癌前状态
人乳头瘤病毒16
宫颈上皮内瘤样病变
支原体感染
Uterine cervical neoplasms
Precancerous conditions
Human papillomavirus 16
Cervical intraepithelial neoplasia
Mycoplasma infections
