摘要
变应性鼻炎(AR)是特异性免疫球蛋白E介导的鼻黏膜非感染性慢性炎症性疾病,以Th2及其分泌的IL-4、IL-5参与主要炎症过程。B淋巴细胞诱导成熟蛋白-1(Blimp-1)是一种含锌指基序的转录抑制因子,调控T细胞发育、分化和功能,对活化T淋巴细胞增殖分化和免疫自稳有重要的调节作用。鉴于Blimp-1对于下呼吸道及其他变应性炎症反应疾病有抗炎作用,深入探寻Blimp-1在AR发生发展中可能的作用,对研究AR的发病机制、新的治疗方法、改善症状、降低并发症具有重大意义。本文对Blimp-1在AR发病机制中的作用及其研究进展进行综述。
Allergic Rhinitis(AR)is a non-infectious chronic inflammatory disease of nasal mucosa mediated by specific immunoglobulin E(Ig E),in which Th2 and its secreted IL-4 and IL-5 are involved in the main inflammatory process.B lymphocyte-inducible maturation protein-1(Blimp-1)is a transcription inhibitor containing zinc finger motifs.Blimp-1 regulates the development,differentiation and function of T cells.Blimp-1 plays an important role in regulating the proliferation and differentiation of activated T lymphocytes and immune homeostasis.Blimp-1 plays an important role in regulating the proliferation and differentiation of activated T lymphocytes and immune self-stabilization.It is of great significance to explore the possible role of Blimp-1 in the occurrence and development of AR for the anti-inflammatory effects of Blimp-1 on the lower respiratory tract and other allergic inflammatory response diseases.It is great value for studying blimp-1 related to the pathogenesis,new treatment methods,improvement of symptoms and reduction of complications of AR.Therefore,this paper reviews the role of Blimp-1 in the pathogenesis of AR and its research progress.
作者
张建
李同丽
ZHANG Jian;LI Tongli(Shanxi Medical University,Taiyuan 030001,China;Department of Otolaryngology Head and Neck Surger,People’s Hospital Affiliated to Shanxi Medical University,Taiyuan 030012,China)
出处
《中国耳鼻咽喉颅底外科杂志》
CAS
2022年第1期65-68,共4页
Chinese Journal of Otorhinolaryngology-skull Base Surgery
基金
2021年山西省基础研究计划(自由探索类晋财教[2021]31号,20210302123353)。
