摘要
目的探讨临床甲状腺功能亢进症(hyperthyroidism,HT)、亚临床甲状腺功能亢进症(简称亚甲亢)患者血清神经调节蛋白4(Nrg4)、Tsukushi(TSK)水平与血脂、甲状腺激素、基础代谢率(basal metabolic rate,BMR)的相关性。方法纳入黑龙江省红十字(森工总)医院2018年12月~2020年12月收治的HT患者150例、亚甲亢患者130例分别作为HT组、亚甲亢组,选取同期该院体检的健康志愿者80例作为表观健康组。比较三组血清Nrg4,TSK水平以及血脂指标[总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)]、甲状腺激素指标[TSH、甲状旁腺素(PTH)、游离甲状腺素(FT4)、游离三碘甲状腺原氨酸(FT3)、总三碘甲状腺原氨酸(TT3),总甲状腺素(TT4)]和BMR,分析患者血清Nrg4,TSK水平与血脂、甲状腺激素、BMR的相关性,观察血清Nrg4与TSK的相关性。结果HT组血清Nrg4,TSK,PTH,FT4,FT3,TT3,TT4和BMR高于亚甲亢组(t=9.591~29.295,均P<0.05)和表观健康组(t=11.543~26.872,均P<0.05),而血清TSH,TC,TG,LDL-C和HDL-C水平低于亚甲亢组(t=3.776~27.429,均P<0.05)和表观健康组(t=3.531~17.533,均P<0.05),差异均有统计学意义。亚甲亢组血清Nrg4,TSK水平高于表观健康组(t=5.277,7.008,均P<0.05),但HDL-C,TSH水平低于表观健康组(t=10.358,28.220,均P<0.05),差异均有统计学意义。Pearson线性相关分析提示HT患者血清Nrg4,TSK水平与血清TC,LDL-C,HDL-C和TSH水平呈负相关(r=-0.652~-0.371,均P<0.05),与血清PTH,FT4,FT3,TT3,TT4及BMR呈正相关(r=0.349~0.593,均P<0.05);亚甲亢患者血清Nrg4,TSK水平与HDL-C,TSH水平呈负相关(r=-0.615~-0.489,均P<0.05);HT,亚甲亢患者血清Nrg4与TSK水平均呈正相关(r=0.581,0.563,均P<0.05)。结论针对性别、年龄、吸烟史、饮酒史混杂因素进行校准,并将上述因素剔除后发现HT,亚甲亢患者血清Nrg4,TSK水平均增高,且HT患者的Nrg4,TSK与血脂、甲状腺激素和BMR有明显相关性,而亚甲亢患者的Nrg4,TSK仅与HDL-C,TSH有关。
Objective To investigate the correlation between serum neuregulin 4(Nrg4),tsukushi(TSK)levels and blood lipid,thyroid hormone,basal metabolic rate(BMR)in patients with clinical hyperthyroidism(HT)and subclinical hyperthyroidism(hereinafter referred to as sub hyperthyroidism).Methods A total of 150 HT patients and 130 subthyroidism patients who were admitted to Heilongjiang Red Cross Hospital from December 2018 to December 2020 were included as HT group and subthyroidism group,respectively.80 healthy volunteers who received physical examination in the hospital during the same period were selected as the apparent health group.The serum Nrg4,TSK levels and blood lipids indexes[total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C)],thyroid hormone indexes[thyroid stimulating hormone(TSH)and parathyroid hormone(PTH)and free thyroxine(FT4),free triiodothyronine(FT3),total triiodothyronine 3(TT3),total thyroxine(TT4)]and BMR in three groups were compared.The correlation between serum Nrg4 and TSK levels and blood lipid,thyroid hormone and BMR was analyzed,and the correlation between serum Nrg4 and TSK was observed.Results The serum Nrg4,TSK,PTH,FT4,FT3,TT3,TT4 and BMR in HT group were higher than those in subthyroidism group(t=9.591~29.295,all P<0.05),and apparent health group(t=11.543~26.872,all P<0.05),while the serum TSH,TC,TG,LDL-C and HDL-C levels were lower than those in subthyroidism group(t=3.776~27.429,all P<0.05),and apparent health group(t=3.531~17.533,all P<0.05),the difference were statistically significant,respectively.The serum Nrg4 and TSK levels in subthyroidism group were higher than those in apparent health group(t=5.277,7.008,all P<0.05),but the HDL-C and TSH levels were lower than those in apparent health group(t=10.358,28.220,all P<0.05),the difference were statistically significant,respectively.Pearson linear correlation analysis showed that serum Nrg4,TSK levels were negatively correlated with serum TC,LDL-C,HDL-C and TSH levels in HT patients(r=-0.652~-0.371,all P<0.05),and positively correlated with serum PTH,FT4,FT3,TT3,TT4 and BMR(r=0.349~0.593,all P<0.05).The serum Nrg4 and TSK levels were negatively correlated with the HDL-C and TSH levels in subthyroidism patients(r=-0.615~-0.489,all P<0.05).Serum Nrg4 and TSK levels were positively correlated in HT and subthyroidism patients(r=0.581,0.563,all P<0.05).Conclusion The confounding factors such as gender,age,smoking history and drinking history were adjusted.After eliminating the above factors,it was found that serum Nrg4 and TSK levels in patients with HT and hypothyroidism were increased,and Nrg4,TSK and blood lipids,thyroid hormones and BMR in HT patients were significantly increased.Correlation,while Nrg4 and TSK in patients with hypothyroidism were only related to HDL-C and TSH.
作者
魏巍
张旭
李婉娇
宋禹青
罗莎
张皓
WEI Wei;ZHANG Xu;LI Wan-jiao;SONG Yu-qing;LUO Sha;ZHANG Hao(Department of Endocrinology and Metabolism,Heilongjiang Red Cross Hospital/Sengong General Hospital,Harbin,150040,China;Department of General Surgery,Heilongjiang Red Cross Hospital/Sengong General Hospital,Harbin,150040,China)
出处
《现代检验医学杂志》
CAS
2022年第1期38-42,47,共6页
Journal of Modern Laboratory Medicine
基金
2018年黑龙江省自然科学基金项目(H20180061)。
