摘要
目的探讨伴卵圆孔未闭(PFO)偏头痛患者头痛程度的影响因素。方法回顾性分析2013年1月至2019年6月大连医科大学附属大连市中心医院124例伴PFO偏头痛患者的临床资料。经颅多普勒超声发泡试验(c-TCD)检查评估PFO右向左分流量;经食管超声心动图(TEE)检测PFO直径、PFO隧道长度及是否伴有房间隔膨出瘤(ASA);采用头痛影响测定-6(HIT-6)量表评估偏头痛程度。PFO右向左分流量和PFO直径与偏头痛程度比较采用Goodman-Kruskalγ检验;PFO隧道长度和ASA与偏头痛程度比较采用Spearman秩相关分析。结果124例PFO伴偏头痛患者中,c-TCD检测结果显示,小分流量20例,中分流量31例,大分流量73例。TEE检测结果显示,小卵圆孔76例,中卵圆孔47例,大卵圆孔1例;长隧道57例,短隧道67例;无ASA 91例,伴有ASA 33例。HIT-6评分结果显示,一定影响9例,明显影响22例,严重影响93例。Goodman-Kruskalγ检验结果显示,PFO右向左分流量和PFO直径与偏头痛程度呈正相关(γ=0.66,P<0.01;γ=0.38,P<0.05)。Spearman秩相关分析结果显示,伴有ASA与偏头痛程度呈正相关(r=0.18,P<0.05),PFO隧道长度与偏头痛程度呈负相关(r=-0.23,P<0.05)。结论PFO右向左分流量、PFO直径、伴有ASA与偏头痛程度呈正相关,PFO隧道长度与偏头痛程度呈负相关。
Objective To investigate the influencing factors of headache degree in migraine patients with patent foramen ovale(PFO).Methods The clinical data of 124 migraine patients with PFO from January 2013 to June 2019 in Dalian Central Hospital Affiliated to Dalian Medical University were retrospectively analyzed.The right-to-left shunt of PFO was assessed by contrast-enhanced transcranial Doppler(c-TCD);the diameter of PFO,length of PFO tunnel and the presence of atrial septal aneurysm(ASA)were detected by transesophageal echocardiography(TEE);the degree of migraine was assessed by headache impact test-6(HIT-6)scale.The relations between right-to-left shunt volume of PFO,diameter of PFO and degree of migraine were analyzed by Goodman-Kruskalγtest;the relations between the length of PFO tunnel,ASA and degree of migraine were analyzed by Spearman rank correlation analysis.Results Among the 124 migraine patients with PFO,the c-TCD test result showed that small shunt volume was in 20 cases,medium shunt volume in 31 cases,and large shunt volume in 73 cases.The TEE test result showed that small foramen ovale in 76 cases,medium foramen ovale in 47 cases,and large foramen ovale in 1 case;long tunnel in 57 cases,and short tunnel in 67 cases;without ASA in 91 cases,and with ASA in 33 cases.The HIT-6 score result showed that some influence in 9 cases,significantly influence in 22 cases,and serious influence in 93 cases.The Goodman-Kruskalγtest result showed that right-to-left shunt volume of PFO and diameter of PFO were positive correlation with degree of migraine(γ=0.66,P<0.01;γ=0.38,P<0.05).The Spearman rank correlation analysis result showed that ASA was positive correlation with degree of migraine(r=0.18,P<0.05),while the length of PFO tunnel was negative correlation with degree of migraine(r=-0.23,P<0.05).Conclusions The right to left shunt amount of PFO,diameter of PFO and the presence of ASA are positive correlation with degree of migraine,while the length of PFO tunnel is negative correlation with degree of migraine.
作者
潘心
刘凡
李福荣
李冬平
张美艳
隋晓雯
刘金洁
赵红玲
Pan Xin;Liu Fan;Li Furong;Li Dongping;Zhang Meiyan;Sui Xiaowen;Liu Jinjie;Zhao Hongling(Department of Neurology,Dalian Central Hospital Affiliated to Dalian Medical University,Dalian 116033,China;Department of Neurology,Beijing Yanhua Hospital,Beijing 102500,China;Department of Critical Illness Medicine,Affiliated Hospital of Putian College,Putian 351100,China;Department of General Medicine,Dalian Central Hospital Affiliated to Dalian Medical University,Dalian 116033,China)
出处
《中国医师进修杂志》
2022年第1期49-53,共5页
Chinese Journal of Postgraduates of Medicine
关键词
偏头痛
卵圆孔
未闭
头痛
因素分析
统计学
回顾性研究
Migraine disorders
Foramen ovale,patent
Headache
Factor analysis,statistical
Retrospective studies
