摘要
目的评估系统性红斑狼疮(systemic lupus erythematosus,SLE)患者中性粒细胞/淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)与疾病活动度的关联性。方法选取昆明医科大学第一附属医院风湿免疫科确诊的SLE患者共536例。根据SLE疾病活动指数(SLEDAI)评分,将患者分为疾病无活动组,轻度活动组,中度活动组,重度活动组。比较4组间NLR的差异,并通过Spearman相关性分析,分析NLR与SLE患者疾病活动度的相关性。结果4组间NLR水平有差异,进一步两两比较,结果显示疾病中度活动组NLR水平高于无活动组(调整后P<0.001);重度活动组NLR水平高于无活动组(调整后P<0.001);重度活动组NLR水平高于轻度活动组(调整后P=0.011)SLE患者的NLR与SLEDAI评分呈正相关(P<0.05)。结论NLR可作为评价SLE患者疾病活动度的一项参考指标。
Objective To assess the correlation between neutrophil-lymphocyte ratio(NLR)and the disease activity of systemic lupus erythematosus(SLE).Methods A total of 536 patients with SLE from the Department of Rheumatology and Immunology of the First Affiliated Hospital of Kunming Medical University were selected.According to the SLE Disease Activity Index(SLEDAI)score,patients with SLE were divided into inactive group,lightly active group,moderately active group,and severely active group.The differences in NLR among the four groups were compared,and the correlation between NLR and SLEDAI score was analyzed through Spearman correlation analysis.Results There were differences in NLR levels among the four groups.The results of pairwise comparison showed that the NLR level of the moderately active group was higher than that of the inactive group(adjusted P<0.001);the NLR level of the severely active group was higher than that of the inactive group(adjusted P<0.001);the NLR level of the severely active group was higher than that of the lightly active group(P=0.011 after adjustment).The NLR of SLE patients were positively correlated with SLEDAI scores(P<0.05).Conclusion NLR can be used as a reference index to evaluate the disease activity of SLE patients.
作者
马立花
王湘宇
杨一帆
赵若彤
丰晓妍
徐健
MA Lihua;WANG Xiangyu;YANG Yifan;ZHAO Ruotong;FENG Xiaoyan;XU Jian(Dept.of Rheumatology and Immunology,the First Affiliated Hospital of Kunming MedicalUniversity,Kunming Yunnan 650032,China)
出处
《昆明医科大学学报》
CAS
2022年第2期78-81,共4页
Journal of Kunming Medical University
基金
国家自然科学基金资助项目(81760296,81460256)
云南省教育厅科学研究基金项目(2021J032)
云南省医疗卫生单位内设研究机构科研项目(2017NS051,2018NS0133)
风湿免疫性疾病多中心临床科研转化平台项目(2018ZF016)
云南省皮肤与免疫疾病临床医学研究中心项目(2019ZF012)
云南省皮肤免疫性疾病临床医学中心项目(ZX2019-03-02)
云南省高层次卫生技术人才(领军人才)项目(L-2019004)
云南省“万人计划”名医人才专项项目(YNWR-MY-2018-040)。
