摘要
目的探讨血必净注射液对重症急性胰腺炎的临床效果及对炎症因子水平的调节作用。方法选取2019年7月至2020年9月赣南医学院第一附属医院收治的60例重症胰腺炎患者为研究对象,采用奇偶数字分配法分为对照组(30例)和试验组(30例)。对照组采用常规治疗方法,试验组采用常规治疗联合血必净治疗方案。比较两组住院治疗时间、炎症因子水平、不良反应发生率和死亡率。结果治疗前,两组患者的白细胞介素-6(IL-6)、血清C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平比较,差异无统计学意义(P>0.05);治疗后,试验组的IL-6、hs-CRP、TNF-α水平均低于对照组,差异有统计学意义(P<0.05)。试验组机械通气维持时间、重症监护病房(ICU)停留时间、住院时间均短于对照组,且试验组不良反应总发生率、死亡率低于对照组,差异有统计学意义(P<0.05)。结论在常规治疗的基础上应用血必净注射液进行治疗,有助于改善重症急性胰腺炎患者的炎症指标,利于提升治疗效果,短缩住院治疗时间,疗效肯定,值得推广。
Objective To explore the clinical effect of Xuebijing Injection on severe acute pancreatitis and its regulating effect on the level of inflammatory factors.Methods A total of 60 patients with severe pancreatitis admitted to our hospital from July 2019 to September 2020 were selected as the research objects,and they were divided into the control group(30 cases)and the experimental group(30 cases)using the parity number assignment method.The control group was treated with conventional treatment,and the experimental group was treated with conventional treatment combined with Xuebijing treatment plan.Time of hospitalization,inflammatory factor levels,incidence of adverse reactions,and mortality were compared between the two groups.Results Before treatment,there was no significant difference in the levels of interleukin-6(IL-6),serum C-reactive protein(hs-CRP),and tumor necrosis factor-α(TNF-α)between the two groups of patients(P>0.05).After treatment,the IL-6,hs-CRP and TNF-αin the experimental group were lower than those in the control group,and the differences were statistically significant(P<0.05).The maintenance time of mechanical ventilation,intensive care unit(ICU)stay,and hospital stay in the experimental group were shorter than those in the control group,and the total incidence of adverse reactions and mortality in the experimental group were lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion On the basis of conventional treatment,the application of Xuebijing Injection for treatment can help to improve the inflammatory indexes of patients with severe acute pancreatitis,which is beneficial to improve the treatment effect,shorten the length of hospitalization,and the curative effect is positive.It is worthy of promotion.
作者
刘欣
陈辉
林洁
邹康
尹康
赖纪英
LIU Xin;CHEN HuiLIN Jie;ZOU Kang;YIN Kang;LAI Jiying(Department of Critical Care Medicine,the First Affiliated Hospital of Gannan Medical College,Jiangxi Province,Ganzhou341000,China)
出处
《中国当代医药》
CAS
2022年第5期43-45,共3页
China Modern Medicine
基金
江西省中医药管理局科技计划项目(2020B0302)。
关键词
血必净注射液
重症急性胰腺炎
炎症指标
调节作用
不良反应发生率
死亡率
Xuebijing Injection
Severe acute pancreatitis
Inflammatory index
Regulating effect
Incidence of adverse reactions
Mortality
