摘要
目的探讨高频超声检查结合粗针穿刺活检(CNB)在鉴别乳腺癌中的应用及其与血清糖类抗原153(CA153)、CA125的相关性。方法选取138例乳腺肿块患者,经术后病理检查明确为乳腺癌患者71例作为乳腺癌组,67例乳腺良性病变患者为良性乳腺疾病组,比较各组CNB结果以及血清CA125、CA153水平,分析高频超声结合CNB对乳腺癌的诊断价值。结果138例乳腺肿物患者经高频超声引导下CNB病理检查,发现乳腺良性病变69例(50.00%),乳腺癌69例(50.00%),与肿物切除术后病理检查比较,高频超声引导下CNB检查对乳腺癌的鉴别准确率为94.20%,灵敏度92.96%,特异度95.52%。乳腺癌组患者血清糖类抗原125(CA125)、CA153均高于良性乳腺疾病组,差异有统计学意义(P<0.05)。经Pearson相关分析,超声检查显示肿物边界不清晰、形态不规则、内部回声不均匀、CNB检查恶性的乳腺肿块患者血清CA153、CA125的表达高于边界清晰、形态规则、内部回声均匀、CNB检查良性的患者(P<0.05)。结论肿瘤标志物CA125、CA153的表达与乳腺癌超声表现、CNB检查和术后病理结果密切相关,高频超声引导下的CNB可对乳腺癌进行较准确的鉴别,为乳腺肿块患者提供较准确的治疗指导。
Objective To explore the application of high frequency ultrasound combined with core needle biopsy(CNB)in the identification of breast cancer and their correlation with serum carbohydrate antigen 153(CA153).Methods Of the 138 patients with breast lumps,it was confirmed by postoperative pathological examination that there were 71 cases with breast cancer(breast cancer group)and 67 cases with benign breast lesions(benign breast disease group).CNB results and levels of serum CA153,CEA and CA199 were compared between the 2 groups.Diagnostic value of high-frequency ultrasound combined with CNB for breast cancer was analyzed.Results Of the 138 patients with breast lumps confirmed by CNB examination under the guidance of high-frequency ultrasound,there were 69 cases with benign breast lesions(50.00%)and 69 cases with breast cancer(50.00%).Compared with pathological examination after tumor resection,accuracy,sensitivity and specificity of CNB under guidance of high frequency ultrasound for identifying breast cancer were 94.20%,92.96%and 95.52%,respectively.The serum carbohydrate antigen 125(CA125)and CA153 in breast cancer group were higher than those in benign breast disease group(P<0.05).According to Pearson correlation analysis,ultrasound examination showed unclear borders of tumors,irregular morphology and uneven internal echoes.and CNB examination.The levels of serum CA153 and CA125 in patients with malignant breast lumps were higher than those in benign patients with clear borders,regular morphology and uniform internal echoes by CNB examination(P<0.05).Conclusion The expression of tumor marker CA153 is closely related to ultrasound findings of breast cancer,CNB examination and postoperative pathological results.CNB under guidance of high frequency ultrasound can identify breast cancer more accurately,which can provide more accurate treatment guidance for patients with breast lumps.
作者
陈爽冉
岳玉桃
张芳
韩翠锋
张周龙
CHEN Shuangran;YUE Yutao;ZHANG Fang(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,471003)
出处
《实用癌症杂志》
2022年第2期315-318,共4页
The Practical Journal of Cancer
基金
河南省科技攻关计划项目(编号:182102310592)。
