摘要
目的研究呼气末正压通气(PEEP)治疗对慢阻肺患者呼吸功能的影响。方法选取2018年12月-2021年4月我院收治的慢阻肺合并呼吸衰竭患者48例为研究对象,采用随机数字表法分为对照组和观察组,各24例。对照组采用机械通气治疗,观察组在对照组的基础上给予PEEP治疗,比较两组治疗总有效率、血气指标、肺功能指标、呼吸力学指标及并发症发生情况。结果观察组的治疗总有效率为87.50%,高于对照组的75.00%,差异有统计学意义(P<0.05);两组PaO_(2)、SaO_(2)均高于治疗前,PaCO_(2)均低于治疗前,且观察组PaO_(2)、SaO_(2)高于对照组,PaCO_(2)低于对照组,差异有统计学意义(P<0.05);两组VCmax、FEV1、PEF均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);观察组气道峰压、气道阻力均低于对照组,差异有统计学意义(P<0.05);观察组并发症发生率为8.33%,低于对照组的20.83%,差异有统计学意义(P<0.05)。结论 PEEP治疗慢阻肺合并呼吸衰竭患者效果确切,可提高总有效率,改善血气指标,提高肺功能指标,降低气道阻力,预防并发症的发生,安全性较好。
Objective To study the effect of positive end expiratory pressure ventilation(PEEP) on respiratory function in patients with COPD.Methods A total of 48 patients with chronic obstructive pulmonary disease complicated with respiratory failure admitted to our hospital from December 2018 to April 2021 were selected as subjects.They were divided into control group and observation group by random number table method,with 24 cases in each group.The control group was treated with mechanical ventilation,and the observation group was treated with PEEP on the basis of the control group.The total effective rate,blood gas index,pulmonary function index,respiratory mechanics index and complications were compared between the two groups.Results The total effective rate of the observation group was 87.50%,which was higher than 75.00% of the control group,and the difference was statistically significant(P<0.05).PaO_(2) and SaO_(2) in the two groups were higher than those before treatment,PaCO_(2) was lower than that before treatment,and PaO_(2) and SaO_(2) in the observation group were higher than those in the control group,PaCO_(2) was lower than that in the control group,the difference was statistically significant(P<0.05).VCmax,FEV1 and PEF in the two groups were higher than those before treatment,and those in the observation group were higher than those in the control group,the difference was statistically significant( P <0.05).The airway peak pressure and airway resistance in the observation group were lower than those in the control group,and the difference was statistically significant( P<0.05).The incidence of complications in the observation group was 8.33%,which was lower than 20.83% in the control group,and the difference was statistically significant(P<0.05).Conclusion PEEP is effective in the treatment of patients with chronic obstructive pulmonary disease complicated with respiratory failure,which can improve the total effective rate,improve blood gas indexes,improve lung function indexes,reduce airway resistance,prevent complications,and has good safety.
作者
李龙勇
刘定华
王成连
叶琼瑶
LI Long-yong;LIU Ding-hua;WANG Cheng-lian;YE Qiong-yao(Department of Critical Medicine,Ganzhou Cancer Hospital,Ganzhou 341000,Jiangxi,China)
出处
《医学信息》
2022年第4期130-132,共3页
Journal of Medical Information
关键词
呼气末正压通气
慢阻肺
呼吸衰竭
呼吸功能
Positive end pressure pressure ventilation
Chronic obstructive pulmonary disease
Aspiration failure
Aspiration function
