摘要
目的观察三黄理湿方治疗湿热浸淫型急性湿疹的临床疗效及安全性。方法将72例湿热浸淫型急性湿疹患者随机分为治疗组和对照组各36例。两组患者均外用3%硼酸洗液,治疗组再给予三黄理湿方口服,每日1剂;对照组再给予西替利嗪片口服,每日10 mg,晚餐时口服,两组均治疗2周。比较两组患者治疗前后湿疹面积及严重度指数评分(EASI评分)、瘙痒时间占夜间睡眠的百分比(PIT值)、瘙痒程度视觉模拟评分(VAS评分)、中医证候评分及外周血白细胞介素-4(IL-4)水平、嗜酸性粒细胞计数(EOS)。治疗后评价临床疗效,比较两组愈显患者治疗结束1个月后的复发率,并观察不良反应。结果治疗组EASI评分、PIT值、VAS评分和中医证候评分,血清IL-4和EOS水平均明显低于治疗前(P<0.05或P<0.01)。与对照组比较,治疗组EASI评分、PIT值和中医证候评分均较治疗前下降更明显(P<0.01),EOS较治疗前下降优于对照组(P<0.05);治疗组愈显率(47.2%)优于对照组(19.4%,P<0.05);治疗组17例愈显患者中有3例出现复发,对照组7例愈显患者中有5例出现复发。两组均无明显不良反应。结论口服三黄理湿方治疗湿热浸淫型急性湿疹疗效明显,可有效减少炎症反应,改善患者中医症状。
Objective To evaluate the effectiveness and safety of Sanhuang Lishi Formula(三黄理湿方,SLF)for acute eczema with damp-heat immersion pattern.Methods Seventy-two acute eczema patients with damp-heat immersion pattern were randomized into intervention group and control group,with 36 patients in each group.All pa⁃tients were given topical 3%boric acid lotion,and additionally those in the intervention group were administered with oral SLF,one dose daily,while those in the control group were given oral cetirizine tablets,10mg daily at dinner time;the course of treatment was 2 weeks.The eczema area and severity index(EASI)score,the percent of itching time(PIT)in night sleep,the visual analogue scale(VAS)score of pruritus,traditional Chinese medicine(TCM)symptoms score,peripheral blood interleukin-4(IL-4),and eosinophil count(EOS)were evaluated and compared before and after treatment;the 1-month recurrence rate in cured or markedly effective patients were compared between two groups,and the adverse reactions were observed.Results The EASI score,PIT,VAS score,TCM symptom score,serum IL-4 and EOS in the intervention group significantly decreased after treatment(P<0.05);the cured and markedly effective rate of the intervention group was 47.2%,and the total effective rate was 80.6%.Compared to those in the control group,the decreases of the EASI score,PIT and TCM symptom score in the intervention group were more significant(P<0.01);the decrease of EOS was more significant(P<0.05);and the cured and markedly effective rate was higher(P<0.05).There were 3 recurrent cases in 17 cured and markedly effective cases in the in⁃tervention group,while 5 of 7 reappeared in the control group.There were no obvious adverse reactions in the two groups.Conclusion Oral SLF has significant effect in the treatment of acute eczema with damp-heat immersion pat⁃tern,which can reduce the inflammatory reaction and improve the patient's TCM syndromes.
作者
徐平
马欣
丁佩军
XU Ping;MA Xin;DING Peijun(Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai,201203)
出处
《中医杂志》
CSCD
北大核心
2022年第3期251-255,共5页
Journal of Traditional Chinese Medicine
基金
上海市卫生和计划生育委员会、上海市中医药发展办公室上海市海派中医流派传承人才培养项目(LPRC2017041)
上海市卫生和计划生育委员会科研课题(20184Y0020)。
关键词
急性湿疹
三黄理湿方
湿热浸淫型
炎症反应
acute eczema
Sanhuang Lishi Formula(三黄理湿方)
damp-heat immersion pattern
inflammatory reaction
