摘要
目的探究IL-1、hs-CRP、25-OH-D在妊娠期糖尿病(GDM)合并妊娠期亚临床甲状腺功能减退症(SCH)中的早期诊断价值。方法回顾性分析2017年8月至2018年8月本院收治的122例GDM孕妇的临床资料,GDM合并SCH作为GDM合并SCH组(n=61),单纯GDM则作为GDM组(n=61),另外选择同期健康孕妇作为健康妊娠组(n=61);对比分析三组孕妇IL-1、hs-CRP、25-OH-D、甲状腺过氧化物酶抗体(TPOAb)、胰岛素抵抗指数(IRI)水平变化,并行Pearson相关分析。结果三组孕妇IL-1、hs-CRP、25-OH-D水平有显著差异(P<0.05);两组组间比较IL-1、hs-CRP水平,GDM合并SCH组、GDM组均显著高于健康妊娠组(P<0.05),而GDM合并SCH组显著高于GDM组(P<0.05);25-OH-D水平,GDM合并SCH组、GDM组均显著低于健康妊娠组(P<0.05),而GDM合并SCH组显著低于GDM组(P<0.05)。三组孕妇TPOAb、IRI差异显著(P<0.05),且GDM合并SCH组、GDM组显著高于健康妊娠组(P<0.05),而GDM合并SCH组显著高于GDM组(P<0.05)。相关性分析发现,TPOAb、IRI与IL-1、hs-CRP呈正相关(P<0.05),IRI与25-OH-D呈负相关(P<0.05)。ROC曲线分析结果显示,IL-1、hs-CRP、25-OH-D、三者联合诊断AUC分别为0.884、0.860、0.724、0.905。结论血清IL-1、hs-CRP、25-OH-D与GDM合并SCH有密切关系,临床可结合三者水平对GDM合并SCH进行预测,并作为临床干预的主要依据。
Objective To explore the early diagnostic value of IL-1,hs-CRP,25-OH-D in gestational diabetes mellitus patients complicated with gestational subclinical hypothyroidism.MethodsClinical data of 122 GDM patients who were treated in the study hospital from August 2017 to August 2018 were retrospectively analyzed.GDM with SCH group included 61 patients,and pure GDM group included 61 patients.Another 61 healthy pregnant women who were treated in the study hospital during the same period were selected as control group.The differences in the levels of IL-1,hs-CRP,25-OH-D,thyroid peroxidase antibody(TPOAb)and insulin resistance index(IRI)among the three groups were examined,and the Pearson correlation coefficients between these indicators were calculated.ResultsThere were significant differences in the levels of IL-1,hs-CRP,and 25-OH-D among the three groups(P<0.05);the levels of IL-1,hs-CRP in the GDM with SCH group and the GDM group were significantly higher than those of the healthy control group(P<0.05),and the levels of these three indicators were significantly higher in the GDM with SCH group than the GDM group(P<0.05).The levels of 25-DH-D in the GDM with SCH group and the GDM group were significantly lower than that in the healthy control group(P<0.05),and the level of 25-DH-D in the GDM with SCH group was significantly lower than that in the GDM group(P<0.05).There were significant differences in the levels of TPOAb and IRI among the three groups(P<0.05);the levels of TPOAb and IRI in the SCH with GDM group and the GDM group were significantly higher than the healthy control group(P<0.05),and the levels of these two indicators were significantly higher in the SCH with GDM group than the GDM group(P<0.05).In the correlation analysis,the levels of TPOAb and IRI were positively correlated with IL-1 and hs-CRP(P<0.05),while IRI was negatively correlated with 25-OH-D(P<0.05).The ROC curve analysis showed that AUC of IL-1,hs-CRP,25-OH-D and the combination of these three indicators were 0.884,0.860,0.724 and 0.905,respectively.ConclusionThe serum IL-1,hs-CRP,25-OH-D is associated with GDM with SCH,and the levels of these indicators may be used to predict the occurrence of GDM with SCH.These findings may be used as the basis for clinical intervention.
作者
王芳
王秀梅
郭亚利
邢梅
WANG Fang;WANG Xiumei;GUO Yali;XING Mei(Department of Obstetrics and Gynecology, the sixth medical center, PLA General Hospital, Beijng 100048, China)
出处
《中国生育健康杂志》
2022年第2期141-144,161,共5页
Chinese Journal of Reproductive Health
基金
海军总医院创新培育基金(HLCX-2017-12)。
