摘要
目的:探索中药粉体的物理性质加和性特征,采用欧氏距离比推测出难粉碎的油性中药物料苦杏仁的粉体学物理性质。方法:以山药、益母草、煅牡蛎、党参、苦杏仁为粉性料、纤维性料、脆性料、糖性料、油性料的代表性物料,将上述中药细粉按照一定的比例两两混合,得到26份单味或混合中药的粉体,测定26份中药粉体的堆密度、吸水率、最大转矩力等15个物理参数,表征中药粉体的基础性质、吸水性和转矩流变性。运用SIMCA-P 14.1和Excel软件进行主成分分析及相关性分析,将推测出的苦杏仁物理性质与原26份中药粉体物理性质再次进行主成分分析,并对混合粉体占比与主成分加权平均得分进行相关性验证。结果:在山药-益母草组、益母草-煅牡蛎组、山药-苦杏仁组、煅牡蛎-苦杏仁组等共8组中药粉体物理性质主成分加权平均得分与粉体混合比例的相关性方程中,r值在0.896~0.988之间;采用欧氏距离比推测出苦杏仁的粉体学物理性质,物理性质主成分加权平均得分与粉体混合比例的相关性验证结果显示,山药-苦杏仁组r=0.963,煅牡蛎-苦杏仁组r=0.873。结论:不同物理性质分类的粉体按照一定比例混合后,其物理性质具有加和性,利用该性质可以推测出苦杏仁等难以单独粉碎过筛的油性料中药粉体的物理性质,从而更好地指导中药新药及临方制剂技术的研究与开发。
Objective:To explore the additivity property characterics of Chinese medicine powder physical properties,and predict the powder physical properties of oily Chinese medicine Armeniacae Semen Amarum which is hard to crush applying Euclidean distance ratio.Methods:The representative materials of five typical Chinese medicines including powdery,fibrous,brittle,sugar,and oily materials were Dioscoreae Rhizoma,Leonur Iherba,Ostreae Concha,Codonopsis Radix and Armeniacae Semen Amarum respectively. The fine powder of above Chinese medicines were mixed in pairs according to a certain proportion,and 26 powders of single or mixed Chinese medicines were obtained. The 15 physical parameters including bulk density,water absorption rate,maximum torque force and so on of 26 Chinese medicine powders were determined to characterize the basic properties,hydroscopicity and torque rheology of the Chinese medicine powders. The SIMCA-P 14.1 and Excel software were used to carry out the principal component analysis and correlation analysis. The predicted physical properties of Armeniacae Semen Amarum and the physical properties of the original 26 Chinese medicine powders were analyzed again by principal component analysis,and the correlation between the proportion of mixed powders and the weighted average score of principal components was verified.Results:The r value in the correlation equations between the weighted average score of physical property principal component and the mixing ratio of 8 Chinese medicine powder groups including Dioscoreae Rhizoma-Leonur Iherba group,Leonur Iherba-Ostreae Concha group,Dioscoreae Rhizoma-Armeniacae Semen Amarum group,Ostreae Concha-Armeniacae Semen Amarum group,and so on was 0.896-0.988. The powder physical properties of Armeniacae Semen Amarum was predicted by Euclidean distance ratio,and the correlation verification results between the weighted average score of principal component of physical properties and the mixing ratio of powders showed as follows:r=0.963 in Dioscoreae Rhizoma-Armeniacae Semen Amarum group,and r=0.873 in Ostrea Concha-Armeniacae Semen Amarum group.Conclusion:The powder with different physical properties has additive properties after mixing in a certain proportion,the powder physical properties of oily Chinese medicine such as Armeniacae Semen Amarum which is difficult to be crushed and screened alone,could be predicted through the above properties,so as to better guide the research and development of new drug and personalized preparation technology of Chinese medicine.
作者
李云琪
张雪
陈恒晋
沈岚
林晓
王健英
赵立杰
洪燕龙
LI Yunqi;ZHANG Xue;CHEN Hengjin;SHEN Lan;LIN Xiao;WANG Jianying;ZHAO Lijie;HONG Yanlong(Shanghai Traditional Chinese Medicine Health Service Collaborative Innovation Center,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;School of Pharmacy,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Innovative Research Institute of Traditional Chinese Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《上海中医药大学学报》
CAS
2022年第1期49-57,共9页
Academic Journal of Shanghai University of Traditional Chinese Medicine
基金
国家自然科学基金资助项目(81973490)
上海市自然科学基金资助项目(18ZR1436600)
上海市“科技创新行动计划”技术标准项目(20DZ2200900)
上海中医药慢性病防治与健康服务省部共建协同创新中心项目(2021科技02-37)
上海市科技计划项目(21DZ2271000)。
关键词
中药粉体
粉体物理性质
加和性
苦杏仁
中药临方制剂
Chinese medicine powder
physical properties of powder
additive property
Armeniacae Semen Amarum
personalized traditional Chinese medicine preparation
