摘要
目的分析糖代谢异常患者发生亚临床甲减的临床特征及其相关因素,为糖代谢异常者防治亚临床甲减提供理论依据。方法选取2018年3月至2020年3月来天门市第一人民医院内分泌科进行治疗的糖代谢异常患者428例,抽取所有患者空腹肘静脉血5mL,采用全自动免疫分析系统测定血清FT_(3)、FT_(4)、TSH水平;采用全自动分析仪测定包括FBG、HbA1c、TC、TG、LDL-C、UA水平,采用自制问卷调查所有研究代对象性别、年龄、糖代谢异常病程、BMI、血压等基本特征,调查方式采用电话询问和现场调查相结合的方式;采用logistic回归分析糖代谢异常患者发生亚甲减的独立危险因素。结果428例糖代谢异常患者伴有亚临床甲减89例,患病率为20.79%;两组血清FT_(3)、FT_(4)水平间差异无统计学意义(P>0.05);实验组血清TSH水平显著高于对照组(P<0.05);单因素分析两组在年龄、性别、糖代谢异常病程、BMI、BMI、FBG、HbA1c、UA、TC、LDL-C、SBP间差异具有统计学差异(P<0.05);logistic回归分析结果显示高龄、FBG、TC、SBP、UA水平高是糖代谢异常患者发生亚临床甲减的独立危险因素(P<0.05)。结论糖代谢异常患者合并亚临床甲减发病率较高,应定期监测血糖、血脂、血压、尿酸等生化指标,早期对糖代谢紊乱进行调节是防治亚临床甲减的有效途径。
Objective To analyze the clinical situation and related factors of subclinical hypothyroidism in patients with abnormal glucose metabolism,and to provide theoretical basis for the prevention and treatment of subclinical hypothyroidism in patients with abnormal glucose metabolism.Methods A total of 428 patients with abnormal glucose metabolism who were treated in the Department of Endocrinology of Tianmen First People′s Hospital from March 2018 to March 2020 were selected,and serum FT3,FT4 and TSH levels were determined by automatic immune analysis system.Automatic analyzer was used to measure the levels of FBG,HbA1c,TC,TG,LDL-C and UA.A self-made questionnaire was used to investigate the basic information of all subjects,including gender,age,abnormal course of glucose metabolism,BMI and blood pressure.The survey method was combined with telephone inquiry and field investigation.Logistic regression was used to analyze the independent risk factors for subhypothyroidism in patients with abnormal glucose metabolism.Results Among 428 patients with abnormal glucose metabolism,89 patients were accompanied by subclinical hypothyroidism,including 39 males and 43 females,with an average age of(45.12±8.13)years.The prevalence of subhypothyroidism in females was higher than that in males,and the difference was statistically significant(χ^(2)=4.353,P<0.05).There was no significant difference in serum FT_(3) and FT_(4) levels between the two groups(P>0.05).The serum TSH level in experimental group was significantly higher than that in control group(P<0.05).Univariate analysis showed statistically significant differences in age,gender,abnormal course of glucose metabolism,BMI,BMI,FBG,HbA1c,UA,TC,LDL-C and SBP between the two groups(P<0.05).Logistic regression analysis showed that old age,high levels of FBG,TC,SBP and UA were independent risk factors for subclinical hypothyroidism in patients with abnormal glucose metabolism(P<0.05).Conclusion The incidence rate of patients with abnormal glucose metabolism complicated with subclinical hypothyroidism is high.The biochemical indexes such as blood glucose,blood lipid,blood pressure and uric acid should be monitored regularly.The early regulation of glucose metabolism disorder is an effective way to prevent and treat subclinical hypothyroidism.
作者
王瑾
解为慈
刘文
别智霞
WANG Jin;XIE Wei-ci;LIU Wen;BIE Zhi-xia(Department of Endocrinology,First People′s Hospital of Tianmen City,Tianmen,Hubei 431700,China)
出处
《公共卫生与预防医学》
2022年第2期145-148,共4页
Journal of Public Health and Preventive Medicine
