摘要
目的:探究布地奈德福莫特罗联合孟鲁司特钠对哮喘患儿的疗效及对睡眠的影响。方法:选取2020年6月至2021年7月东莞市水乡中心医院儿科收治的小儿哮喘患者100例作为研究对象,按照随机数字表法随机分为对照组和观察组,每组50例。对照组患儿给予口服孟鲁司特钠治疗,观察组在对照组治疗的基础上联用布地奈德福莫特罗吸入剂治疗,比较2组患儿临床疗效、睡眠质量、肺功能指标和炎症指标改善情况。结果:治疗后,观察组患儿总有效率为96.0%,显著高于对照组的84.0%;观察组患儿匹兹堡睡眠质量指数(PSQI)评分(5.52±1.07),显著低于对照组(7.59±1.43);2组患儿FEV1、FVC、PEF以及FEV1/FVC等指标均较治疗前显著改善,且观察组优于对照组;2组患儿IL-5、IgE和ECP水平均较治疗前显著降低,观察组显著低于对照组,以上指标2组比较,差异均有统计学意义(均P<0.05)。结论:布地奈德福莫特罗能够有效降低患儿炎症水平、改善肺功能、提高临床疗效,进而改善睡眠质量。
Objective:To explore the effect of budesonide formoterol combined with montelukast sodium on children with asthma and the effect on sleep.Methods:According to the random number table method,100 pediatric asthma patients admitted to Dongguan Shuixiang Central Hospital from June 2020 to July 2021 were divided into a control group and an observation group,with 50 cases in each group.Children in the control group were treated with oral montelukast sodium,and the observation group was treated with budesonide formoterol inhalation on the basis of the control group.The clinical efficacy,sleep quality,lung function indexes and inflammation indexes of the two groups were counted.Results:After treatment,the total effective rate of children in the observation group was 96.0%,which was significantly higher than 84.0%in the control group;the Pittsburgh Sleep Quality Index(PSQI)score of the children in the observation group was significantly lower than the control group;The FEV1,FVC,PEF,and FEV1/FVC of the children were significantly improved compared to the data before treatment,and the observation group was better than the control group;the levels of IL-5,IgE and ECP of the two groups of children were significantly lower than before treatment,and the observation group was significantly lower than the control group,the difference was statistically significant(P<0.05).Conclusion:Budesonide formoterol can effectively reduce inflammation,improve lung function,improve clinical efficacy,and improve sleep quality in children.
作者
周礼志
ZHOU Lizhi(Department of Pharmacy,Dongguan Shuixiang Central Hospital,Dongguan 523142,China)
出处
《世界睡眠医学杂志》
2021年第12期2133-2135,共3页
World Journal of Sleep Medicine
