摘要
类器官是由干细胞、正常或肿瘤细胞在体外培养获得的,与人体组织结构和功能相似的一种3D细胞模型。近年来,随着类器官培养技术的不断发展和完善,泌尿系统相关类器官模型纷纷建立。该文概述了类器官培养技术在泌尿系统相关研究领域中的应用,包括器官发育及组织修复、肾毒性测试、泌尿系统疾病模型的构建、个性化抗肿瘤药物筛选,同时讨论了泌尿系统类器官模型应用的局限性,并对该项技术广阔的应用前景进行展望。
Organoid is a cellular three-dimensional in vitro model derived from stem cells, normal or tumor cells,and is capable of recapitulating the structure and function of native organs. Over the past decade, this rapidly evolving field has seen the establishment of various organoid models of urinary diseases. This review summarizes the application of organoid culture technology in the research field of urinary system, including organ development and tissue repair, drug nephrotoxicity testing, construction of urinary system disease models, and personalized anti-tumor drug screening. The limitations and promising application prospects of urological organoid models are also discussed.
作者
孟倩
冯晓莹
余磊
倪文秀
陈巍
黄卫人
MENG Qian;FENG Xiao-Ying;YU Lei;NI Wen-Xiu;CHEN Wei;HUANG Wei-Ren(State and Local Government Joint Engineering Laboratory of Synthetic Biology Medicine and Clinical Application of Key Technologies,Shenzhen Second Hospital,Shenzhen 518036,China;Medical College,Shantou University,Shantou 515041,China;Shenzhen Institute of Synthetic Biology,Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences,Shenzhen 518055,China)
出处
《生命科学》
CSCD
北大核心
2022年第1期91-98,共8页
Chinese Bulletin of Life Sciences
基金
国家重点研发计划(2019YFA0906000)
深圳市基础研究重点项目(JCYJ20200108120016553)
广东省自然科学基金项目(2020A1515010235)。
关键词
类器官
泌尿系统
疾病模型
个性化治疗
organoid
urological system
disease modeling
personalized treatment
