摘要
目的观察罗匹尼罗治疗维持性血液透析(MHD)患者不宁腿综合征(RLS)的临床效果。方法选择2018年6月-2020年8月于福建省顺昌县总医院血透中心接受MHD治疗的尿毒症RLS患者78例,采用随机数字表法将患者分为观察组和对照组各39例。2组患者规律血液透析治疗,在此基础上,对照组加左卡尼汀治疗,观察组在对照组的基础上加用罗匹尼罗治疗。比较2组患者治疗前、治疗第8周、16周RLS严重程度评定量表(IRLS)评分、匹兹堡睡眠质量指数(PSQI)评分、夜间肢动情况和不良反应。结果治疗第8、16周,2组患者的IRLS评分、PSQI评分均低于治疗前,夜间肢动次数少于治疗前,且观察组明显低/少于对照组,差异均有统计学意义(P<0.05)。2组患者均无严重不良反应事件发生。结论罗匹尼罗可有效改善MHD患者RLS临床症状和睡眠质量,提高生活质量,药物安全可靠。
Objective To observe the clinical effect of ropinero in the treatment of restless legs syndrome(RLS)in patients with maintenance hemodialysis(MHD).Methods Seventy-eight uremic RLS patients who received MHD treatment in Hemodialysis Center of Shunchang General Hospital of Fujian Province from June 2018 to August 2020 were selected.Patients were divided into observation group and control group with 39 cases in each group by random number table method.Patients in the two groups were regularly treated with hemodialysis,on this basis,the control group was treated with L-carnitine,and the observation group was treated with ropinirole on the basis of the control group.The IRLS score,PSQI score,nocturnal limb movement before treatment,at the 8 th and 16 th week of treatment and adverse reactions were compared between 2 groups.Results At the 8 th and 16 th weeks of treatment,the IRLS score and PSQI score of patients in both groups were lower than before,the number of nocturnal limb movements were less than before treatment,the observation group was significantly lower than that in control group,the differences were statistically significant(P<0.05).There were no serious adverse events in 2 groups.Conclusion Ropinirole can effectively improve the clinical symptoms and sleep quality of MHD patients with RLS,improve living standards,drug safety and reliability.
作者
张汉芹
周小盼
周雯姣
陈忠银
ZHANG Hanqin;ZHOU Xiaopan;ZHOU Wenjiao;CHEN Zhongyin(Shunchang General Hospital,Fujian Province,Shunchang County 353200,China)
出处
《临床合理用药杂志》
2022年第4期36-38,42,共4页
Chinese Journal of Clinical Rational Drug Use
