摘要
目的分析临床中应用克霉唑栓联合胰岛素治疗糖尿病(DM)并发外阴阴道假丝酵母菌病(VVC)对患者疗效影响。方法纳入2019年5月—2021年6月该院收治的92例DM伴VVC患者,利用摸球法进行分组,各46例;对照组患者使用胰岛素+保妇康凝胶治疗,研究组患者联合克霉唑栓+胰岛素治疗,对比两组治疗效果、血糖水平、细胞因子水平变化。结果治疗前,两组2 hBG、FBG水平差异无统计学意义(P>0.05);治疗后,两组血糖水平较治疗前均下降,且研究组患者2 hBG、FBG水平均低于对照组,有统计学意义(P<0.05)。研究组患者总有效率97.83%,高于对照组有效率80.43%,差异有统计学意义(P<0.05)。治疗前,研究组患者INF-γ、INF-α、IL-6、IL-10细胞因子与对照组比较,差异无统计学意义(P>0.05);治疗后,两组患者INF-γ、INF-α水平明显下降,而IL-6、IL-10显著升高,差异有统计学意义(P<0.05),且研究组INF-γ、INF-α水平低于对照组,而IL-6、IL-10水平高于对照组,差异有统计学意义(P<0.05)。结论DM伴VVC患者联合使用克霉唑栓+胰岛素,不仅有助于控制血糖,提高疗效,且有利于调节患者免疫水平。
Objective To analyze the clinical effect of clotrimazole supp combined with insulin in the treatment of diabetes mellitus(DM)complicated with vulvovaginal candidiasis(VVC).Methods 92 DM patients with VVC admitted to the hospital from May 2019 to June 2021 were enrolled and divided into groups by ball-touching method,46 cases in each group.Patients in control group were treated with insulin+Baofukang gel,and patients in study group were treated with clotrimazole supp+insulin.The therapeutic effect,blood glucose level and cytokine level were compared between the two groups.Results Before treatment,there was no statistically significant difference in 2 hBG and FBG levels between the two groups(P>0.05);after treatment,the blood glucose levels of the two groups were lower than before treatment,and the 2 hBG and FBG levels of the study group were lower than those of the control group,the difference was statistically significant(P<0.05).The total effective rate of patients in the study group was 97.83%,higher than the effective rate of the control group 80.43%,the difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference between INF-γ,INF-α,IL-6,IL-10 and other cytokines in the study group and the control group(P>0.05);after treatment,the two groups of patients with INF-γ,INF-αwere significantly decreased,while IL-6 and IL-10 were significantly increased,the difference was statistically significant(P<0.05).The levels of INF-γand INF-αin the study group were lower than those in the control group,while the level of IL-6 and IL-10 were higher than that of the control group,and the difference was statistically significant(P<0.05).Conclusion The combined use of clotrimazole suppositories and insulin in DM with VVC patients is not only helpful to control blood glucose and improve the efficacy,but also to regulate the immune level of patients.
作者
李丽娟
廖勋
LI Lijuan;LIAO Xun(Macheng Maternal and Child Health Hospital,Macheng,Hubei Province,438300 China;Medical College,Hubei University for Nationalities,Enshi,Hubei Province,445000 China)
出处
《糖尿病新世界》
2022年第2期107-110,共4页
Diabetes New World Magazine
关键词
外阴阴道假丝酵母菌病
克霉唑栓
糖尿病
胰岛素
免疫水平
血糖
Vulvovaginal candidiasis
Clotrimazole suppository
Diabetes
Insulin
Immunity level
Blood glucose
