摘要
目的:通过分析住院的成人癫痫患者抗癫痫药物使用情况,总结药物使用相关问题,为临床合理用药提供参考。方法:采用回顾性研究的方法,收集某院2020年1月–2021年6月期间住院的成人癫痫患者病历,运用PCNE-DRPsV8.02分类法进行药物相关问题(DRPs)分类。结果:共收集病历418份,患者年龄主要分布在45~59岁(46.65%)、44.26%患者合并疾病4~6种,以继发性癫痫、继发病因脑血管病等为主。抗癫痫药物丙戊酸钠使用率最高(64.99%),共223例患者(53.35%)进行血药浓度监测。统计得出573个DRPs问题,原因1040个,其中药物选择(41.45%)和剂量选择(31.44%)占比最高。结论:医院抗癫痫药使用存在较多问题,临床药师应及时发现DRPs并反馈至各科室,参与治疗计划,辅助临床合理用药。
Objective:To analyze the use of antiepileptic drugs in hospitalized adult patients with epilepsy,summarize the problems related to drug use,and provide references for clinical rational drug use.Methods:Medical records of hospitalized adult patients with epilepsy in a hospital from January 2020 to June 2021 were retrospectively collected,and drug-related problems(DRPs)were classified by PCNE-DRPs V8.02 classification.Results:A total of 418 medical records were collected,among which the patients were mainly 45–59 years old(46.65%).And 44.26%of patients were complicated with 4–6 kinds of diseases,mainly secondary epilepsy and cerebrovascular diseases.The utilization rate of sodium valproate was the highest(64.99%),in which 223 cases(53.35%)had therapeutic drug monitoring.There were 573 DRPs,and the causes were 1040 cases.Drug selection(41.45%)and dose selection(31.44%)accounted for the highest proportion in cause classification.Conclusion:There were many problems with the use of antiepileptic drugs in hospital.Clinical pharmacists should discover DRPs and feed back to all departments in time,participate in the treatment in order to assist clinical rational drug use.
作者
张今潞
智勇刚
胡杰
王恒
ZHANG Jin-lu;ZHI Yong-gang;HU Jie;WANG Heng(School of Pharmacy,Shihezi University,Shihezi 832000,China;Department of Pharmacy,the First Affiliated Hospital of Medical College of Shihezi University,Shihezi 832000,China)
出处
《中国药物应用与监测》
CAS
2022年第1期51-54,共4页
Chinese Journal of Drug Application and Monitoring
基金
兵团科协科普发展专项(2019CD005)。
关键词
癫痫
抗癫痫药物
药物相关问题
血药浓度监测
合理用药
Epilepsy
Antiepileptic drug
Drug-related problems
Therapeutic drug monitoring
Rational drug use
