摘要
目的观察贝那普利联合比索洛尔治疗高血压合并冠心病患者的临床疗效及其对炎性因子的影响。方法选取2020年1月—2021年1月湖南省职业病防治院收治的高血压合并冠心病患者80例,随机分为用药1组与用药2组,各40例。2组患者均予以基础治疗,在常规治疗基础上用药1组患者予以盐酸贝那普利片治疗,用药2组患者在用药1组治疗基础上予以比索洛尔片治疗。疗程6个月。比较2组临床疗效,治疗前后心功能指标[左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF)]及6 min步行试验(6MWT)、白介素6(IL-6)、肿瘤坏死因子α(TNF-α)、内皮素-1(ET-1)、基质金属蛋白酶-9(MMP-9),并观察2组不良反应。结果用药2组治疗总有效率为92.50%,高于用药1组的62.50%(χ^(2)=10.323,P<0.05)。治疗后,2组LVEDD、LVESD小于治疗前,LVEF高于治疗前,6MWT长于治疗前,且用药2组LVEDD、LVESD小于用药1组,LVEF高于用药1组,6MWT长于用药1组(P<0.01)。治疗后,2组IL-6、TNF-α、ET-1、MMP-9低于治疗前,且用药2组低于用药1组(P<0.01)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论贝那普利联合比索洛尔治疗高血压合并冠心病的临床疗效确切,可有效改善患者的心功能和血压,降低炎性因子水平,且安全性较高。
Objective To discuss the clinical efficacy of benazepril combined with bisoprolol in treating hypertension complicated with coronary heart disease and its influence on inflammatory factors.Methods A total of 80 cases of patients with hypertension complicated with coronary heart disease were selected from January 2020 to January 2021 in Hunan Prevention and Treatment Institute for Occupational Diseases,which were randomly divided into group 1 and group 2,40 cases in each group.On the basis of routine treatment,patients in group 1 were treated with benazepril hydrochloride tablets,patients in group 2 were treated with bisoprolol tablets on the basis of treatment in group 1.Patients in both groups were treated for6 months.Clinical efficacy,cardiac function indexes(LVEDD,LVESD,LVEF),6 MWT,IL-6,TNF-α,ET-1,MMP-9 before and after treatment were compared between the two groups,and the incidence of adverse reactions were observed.Results The total effective rate of group 2 was 92.50%,which was higher than 62.50%of group 1(χ^(2)=10.323,P<0.05).After treatment,LVEDD and LVESD in the two groups were lower than those before treatment,LVEF was higher than that before treatment,6 MWT was longer than that before treatment,and LVEDD and LVESD in group 2 were lower than that in the group 1,LVEF was higher than that in the group 1,and 6 MWT was longer than that in the group 1(P<0.05).After treatment,IL-6,TNF-α,ET-1 and MMP-9 in the two groups were lower than those before treatment,and those in group 2 were lower than those in group 1(P<0.05).There was no significant difference of the incidence of adverse reactions between group 2 and group 1(P>0.05).Conclusion Benazepril combined with bisoprolol have an exact clinical effect for hypertension complicated with coronary heart disease,which can effectively improve the cardiac function and blood pressure of patients,reduce the level of inflammatory factors,and has high safety.
作者
杨园园
王燕
李丹
YANG Yuanyuan;WANG Yan;LI Dan(Hunan Prevention and Treatment Institute for Occupational Diseases,Changsha 410000,China)
出处
《临床合理用药杂志》
2022年第6期20-23,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
高血压
冠心病
贝那普利
比索洛尔
治疗结果
Hypertension
Coronary heart disease
Benazepril
Bisoprolol
Treatment outcome
