摘要
目的探讨糖化血红蛋白及皮质醇联合检测对2型糖尿病患者的诊断价值。方法回顾性分析2019年5月至2020年5月本院收治的118例疑似2型糖尿病患者的临床资料,均有明确诊断结果。118例患者入院后均分别行血清糖化血红蛋白、皮质醇检测,以最终诊断结果为金标准,判断糖化血红蛋白、皮质醇单独与联合检测时的诊断效能。结果 118例疑似2型糖尿病患者最终诊断结果显示,2型糖尿病102例,非2型糖尿病16例;以最终诊断结果为金标准,糖化血红蛋白、皮质醇联合检测阳性检出率为89.83%,高于单独糖化血红蛋白的82.20%、单独皮质醇的81.36%(χ^(2)=4.493、5.205,P=0.034、0.022);糖化血红蛋白、皮质醇联合检测敏感度、准确度、阴性预测值分别为98.04%、91.53%、66.67%,高于单独糖化血红蛋白的90.20%、87.29%、52.38%,高于单独皮质醇的88.24%、84.75%、45.45%。结论 2型糖尿病诊断中联用糖化血红蛋白与皮质醇可提升诊断效能。
Objective To investigate the diagnostic value of glycosylated hemoglobin and cortisol in patients with type 2 diabetes mellitus.Methods The clinical data of 118 patients with suspected type 2 diabetes in our hospital from May 2019 to May 2020 were retrospectively analyzed,and the diagnosis results were clear.All 118 patients were tested for serum glycosylated hemoglobin and cortisol after admission.The final diagnosis results were used as the gold standard to determine the diagnostic efficacy of glycosylated hemoglobin and cortisol.Results The final diagnosis results of 118 suspected type 2 diabetes patients showed that 102 cases were type 2 diabetes and 16 cases were non type 2 diabetes mellitus;the positive rate of combined detection of glycosylated hemoglobin and cortisol was 89.83%,which was higher than 82.20% of glycosylated hemoglobin and81.36% of cortisol alone(χ^(2)=4.493,5.205,P=0.034,0.022).The sensitivity,accuracy and negative predictive value of combined detection of cortisol were 98.04%,91.53% and 66.67%,respectively,which were higher than those of glycosylated hemoglobin alone 90.20%,87.29%,52.38%,and cortisol alone of 88.24%,84.75% and 45.45% respectively.Conclusion The combination of glycosylated hemoglobin and cortisol in the diagnosis of type 2 diabetes can improve the diagnostic efficiency.
作者
王蒨
WANG Qian(Department of Laboratory Medicine,Affiliated Central Hospital of Medical College,Shenyang,Liaoning,110024,China)
出处
《当代医学》
2022年第8期63-65,共3页
Contemporary Medicine
关键词
2型糖尿病
糖化血红蛋白
皮质醇
联合检测
诊断价值
Type 2 diabetes mellitus
Glycosylated hemoglobin
Cortisol
Combined detection
Diagnosis value
