摘要
核因子E2相关因子2(Nrf2)是一种多功能的转录因子,在细胞保护机制中起着至关重要的作用。随着Nrf2调控新模式和新功能研究的不断深入,Nrf2在恶性肿瘤中的促癌作用日益凸显。越来越多的证据表明Nrf2参与了肿瘤的发生、发展、转移和预后的整个过程,抑制Nrf2是一种较有前景的肿瘤治疗策略。目前,Nrf2抑制剂的研究尚处在早期阶段。本文简要介绍Nrf2的生物学功能,以及其在肿瘤发生中的双重作用,并根据结构类型对代表性的Nrf2抑制剂进行综述,为围绕Nrf2调控开发抗肿瘤药物提供借鉴及思路。
Nrf2 is a multi-effect transcription factor,which plays a crucial role in cytoprotective system.With the deepening of research on new regulatory modes and biologic functions of Nrf2,the oncogenic role of Nrf2 in malignant transformed tumors is increasingly obvious.More and more evidences show that Nrf2 is involved in the whole process of tumor occurrence,development,metastasis and prognosis,and inhibiting Nrf2 may be a promising strategy in tumor therapy.However,the development of Nrf2 inhibitors is still in early stage.In this paper,the biological function of Nrf2 and its dual role in tumor are briefly introduced,and representative Nrf2 inhibitors are reviewed according to their structure types,so as to provide reference and ideas for the development of anti-tumor drugs centering on the regulation of Nrf2.
作者
牟伊
宋雨
文帅
王燕
姜正羽
MOU Yi;SONG Yu;WEN Shuai;WANG Yan;JIANG Zheng-yu(College of Pharmacy and Chemistry&Chemical Engineering,Taizhou University,Taizhou 225300,China;Jiangsu Key Laboratory of Drug Design and Optimization,School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)
出处
《药学学报》
CAS
CSCD
北大核心
2022年第2期321-330,共10页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(81703363)
江苏省高校自然科学基金资助项目(21KJB350008)
江苏省“六大人才高峰”资助(YY-110)。
关键词
NRF2
肿瘤
肿瘤化疗
抑制剂
Nrf2
tumor
chemotherapy for cancer
inhibitors
