摘要
肿瘤干细胞(cancer stem cells,CSCs)是一小群具有自我更新和分化潜力,并能产生异质性细胞的肿瘤细胞亚群,该群细胞在肿瘤的发生发展、复发、转移和耐药中起着十分重要的作用,因此通过研发针对CSCs的靶向药物,将为抗肿瘤药物的研究提供新的方向,并为未来根治肿瘤带来新的希望.近年来,大量实验研究证实了盐霉素对多种类型的肿瘤干细胞具有明显的杀伤作用,这些肿瘤包括肝癌、乳腺癌、胃癌、结直肠癌、前列腺癌和骨肉瘤等.盐霉素可以抑制肿瘤干细胞的增殖、分化及转移,并诱导其凋亡.Wnt/β-catenin信号通路是一种在生物进化过程中高度保守的信号系统,与组织的发育和器官形成等生物学过程密切相关,该通路的异常活化在肿瘤及肿瘤干细胞的发生发展中起关键作用.通过靶向阻断异常活化的Wnt信号通路,可以抑制肿瘤细胞和肿瘤干细胞的增殖并诱导其凋亡,因此该通路已经成为抗肿瘤药物领域的研究热点.Wnt/β-catenin信号通路在盐霉素抗肿瘤干细胞过程中起重要作用,本文综述了盐霉素通过调节Wnt/β-catenin信号通路抑制肿瘤干细胞的研究进展.
Cancer stem cells(CSCs)are a small subset of cells able to self-renew,differentiate,and generate heterogenetic cells,which play a vital role in the tumorigenesis,development,recurrence,metastasis and resistance of tumors.Therefore,developing agents targeting CSCs holds promise to eradicate cancer cells in the future,which provides a novel direction for anti-tumor drug research.Recently,a substantial number of experiments have confirmed the killing effect of salinomycin on CSCs in many types of cancers,including liver cancer,breast cancer,gastric cancer,colorectal cancer,prostate cancer,and osteosarcoma.Salinomycin not only inhibits the proliferation,differentiation and metastasis of CSCs,but also induces their apoptosis.The occurrence and development of cancers and CSCs are crucially influenced by the aberrant activation of the Wnt/β-catenin signaling pathway,a highly conservative signaling system in the process of biological evolution closely associated with biological processes such as tissue development and organogenesis.Accordingly,targeting the abnormally activated Wnt signaling pathway could inhibit the proliferation of cancer cells and CSCs,and induce their apoptosis.Wnt/β-catenin signaling pathway plays an essential part in the effect of salinomycin on CSCs.This paper reviews the research progress that salinomycin inhibits CSCs via regulating the Wnt/β-catenin signaling pathway.
作者
黎莹斯
刘博昕
孙琦
吕德生
LI Ying Si;LIU Bo Xin;SUN Qi;LU De Sheng(Department of Pharmacology,Health Science Center,Shenzhen University,Shenzhen 518086,China)
出处
《中国科学：生命科学》
CSCD
北大核心
2022年第2期223-236,共14页
Scientia Sinica(Vitae)
基金
国家自然科学基金(批准号:81802662,22077085,21671137,31970739)
广东省自然科学基金(批准号:2017A030310329)
广东省医学科学技术研究基金(批准号:A2019475)
深圳市基础研究项目(批准号:JCYJ20170817094611664,JCYJ20190808153209537,JCYJ20190808173601655)
SZU medical young scientists program资助。
