摘要
目的 探究中西医结合优化治疗方案对血栓闭塞性脉管炎患者的疗效及对各项理化指标的影响.方法 选取2020年10月至2021年9月山西益康脉管炎医院收治的血栓闭塞性脉管炎患者,按照掷硬币分组法将100例血栓闭塞性脉管炎患者分为参照组和研究组,各50例.参照组患者采取传统西医治疗方案,研究组患者采取中西医结合优化治疗方案.比较两组患者的临床疗效;对两组患者的主要症状、体征进行评分.比较两组患者的血液流变学指标(全血高切黏度、全血低切黏度、血浆比黏度、纤维蛋白原)和血清相关指标[超氧化物歧化酶(SOD)、一氧化氮(NO)、组织型纤维溶酶原激活物(t-PA)].结果 研究组患者的治疗总有效率为96.0%(48/50),高于参照组患者的84.0%(42/50),差异有统计学意义(P=0.046).治疗后,研究组患者主要症状、体征的评分均明显低于参照组患者,差异有统计学意义(P<0.01).治疗后,研究组患者的全血高切黏度、全血低切黏度、血浆比黏度、纤维蛋白原水平均低于参照组患者,差异均有统计学意义(P<0.05).治疗后,研究组患者的血清SOD、NO、t-PA水平均明显高于参照组患者,差异均有统计学意义(P<0.01).结论 采取中西医结合优化治疗方案治疗血管闭塞性脉管炎的疗效确切,能够有效改善患者的症状、体征,降低血液流变学指标水平,改善血清SOD、NO、t-PA水平,有助于患者病情好转,推荐使用.
Objective To explore the effect of cooperation of Chinese and western medicine optimization treatment scheme on patients with thromboangiitis obliterans and its influence on various physical and chemical indexes.Method A total of 100 patients with thromboangiitis obliterans treated in Shanxi Yikang Vasculitis Hospital from October 2020 to September 2021 were divided into reference group and study group,with 50 cases in each group.The patients in the reference group were treated with traditional western medicine,and the patients in the study group were treated with integrated traditional Chinese and western medicine.The clinical effects of the two groups were compared.Score the main symptoms and signs of the two patients.The hemorheological indexes(whole blood high shear viscosity,whole blood low shear viscosity,plasma specific viscosity,fibrinogen)and the serum related indexes[superoxide dismutase(SOD)、nitric oxide(NO)、tissue type plasminogen activator(t-PA)]were compared between the two groups.Result The total effective rate of the study group was 96.0%(48/50),which was higher than 84.0%(42/50)of the reference group(P=0.046).After treatment,the scores of the above main symptoms and signs in the study group were lower than those in the reference group,and the difference was statistically significant(P<0.01).After treatment,the whole blood high shear viscosity,whole blood low shear viscosity,plasma specific viscosity and fibrinogen in the study group were lower than those in the reference group(P<0.05).After treatment,the levels of serum SOD,no and t-PA in the study group were significantly higher than those in the reference group(P<0.01).Conclusion The optimized treatment scheme of integrated traditional Chinese and western medicine is effective in the treatment of vascular occlusive vasculitis.It can effectively improve the symptoms and signs of patients,reduce the level of hemorheological indexes,and improve the levels of serum SOD,No and t-PA.It is recommended to use it.
作者
秦亚鹏
赵玉群
Qin Yapeng;Zhao Yuqun(Department of Peripheral Vasculature,Shanxi Yikang Vasculitis Hospital,Taiyuan 030012,Shanxi,China)
出处
《血管与腔内血管外科杂志》
2021年第11期1302-1306,共5页
Journal of Vascular and Endovascular Surgery
关键词
血栓闭塞性脉管炎
中西医结合优化治疗
疗效
症状
体征
理化指标
thromboangiitis obliterans
cooperation of Chinese and western medicine optimization treatment scheme
effect
symptom
sign
physical and chemical index
