摘要
植物精油是一类具有特殊芳香气味的含有天然生物活性化合物的挥发性混合物。通过对近5年报道的具有抗肿瘤作用的植物精油的化学成分、药理作用及其机制进行总结,表明植物精油可通过抑制增殖、诱导凋亡、阻遏细胞周期、诱导氧化应激、诱导自噬、抑制上皮-间质转化、抑制细胞侵袭迁移和抑制血管生成等途径来发挥抗肿瘤作用,同时归纳了其抗肿瘤作用机制涉及到B淋巴细胞瘤基因-2相关X蛋白(B-cell lymphoma-2 associated X protein,Bax)/B淋巴细胞瘤-2基因(B cell lymphoma-2,Bcl-2)、磷脂酰肌醇3-激酶(phosphatidylinositol3-kinase,PI3K)/蛋白激酶B(protein kinase B,Akt)/雷帕霉素靶蛋白(mechanistic target of rapamycin,mTOR)、HIPPO/Yes激酶相关蛋白(Yes-associated protein,YAP)、表皮生长因子受体(epithelial growth factor receptor,EGFR)、核因子-κB(nuclear factor-κB,NF-κB)、分泌型糖蛋白(Wnt)/β-连环蛋白(β-catenin)和小眼畸形相关转录因子(microphthalmia-associated transcription factor,MITF)等信号通路。此外,汇总了植物精油辅助治疗肿瘤的临床研究以及其与化疗药物联合应用的协同作用效果,并对植物精油用于抗肿瘤用途的主要局限与挑战进行讨论,为植物精油用于抗肿瘤治疗药物的进一步开发和应用提供参考。
Plant essential oils are a kind of volatile mixture with special flavor and natural bioactive compounds.This article summarizes the research on essential oils in recent five years,including its chemical constituents,pharmacological effects and mechanisms of action.It demonstrates that essential oils can exert anti-tumor effects through anti-proliferation,inducing apoptosis of tumor cells,blocking the cell cycle,inducing oxidative stress,inducing autophagy,inhibiting epithelial-mesenchymal transition,inhibiting the invasion and migration and inhibiting angiogenesis.Meanwhile,it is generalized that the anti-tumor mechanism of essential oils are involves in Bax/Bcl-2,PI3K/AKT/mTOR,HIPPO/YAP,EGFR,NF-κB,Wnt/β-catenin and MITF pathways.In addition,this paper summarizes the clinical studies of essential oils in adjuvant therapy of tumors and the synergistic effects of the combined application with chemotherapeutic drugs,and discusses the main limitations and challenges of anti-tumor effect of essential oils and provides references for the further development and application of essential oils in anti-tumor agents.
作者
梁新丽
李秋香
黄小英
赵国巍
谢冰斌
董伟
杨明
LIANG Xin-li;LI Qiu-xiang;HUANG Xiao-ying;ZHAO Guo-wei;XIE Bing-bin;DONG Wei;YANG Ming(Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of ChineseMedicine,Nanchang 330004,China;Department of Otorhinolaryngology Head and Neck Surgery,The Second Affiliated Hospital of Nanchang University,Nanchang330006,China)
出处
《中草药》
CAS
CSCD
北大核心
2022年第4期1252-1263,共12页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金项目(82060733)
国家自然科学基金项目(81660173)
江西省自然基金项目(20181BAB215041)
江西省科技厅2019年度重大科技研发专项(20194ABC28009)
江西中医药大学现代中药制剂教育部重点实验室开放基金(TCM-201911)。
关键词
植物精油
抗肿瘤作用
作用机制
化学成分
安全性
plant essential oils
anti-tumor activity
mechanism of action
chemical constituents
safety
