摘要
2例患者(例1女,59岁;例2女,67岁)分别因中轴型脊柱关节炎和类风湿关节炎应用重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白(rhTNFR:Fc)治疗。例1接受rhTNFR:Fc 50 mg皮下注射、1次/周。治疗3次后双侧上臂出现粟粒大小红色丘疹,伴瘙痒,自行停用rhTNFR:Fc后皮疹减轻;2周后再次使用rhTNFR:Fc,双侧上臂红色丘疹复现并加重,肩背部出现粟粒大小红色丘疹,左踝部出现水肿性红斑,考虑为rhTNFR:Fc所致药疹,停用该药,给予抗过敏治疗10 d后皮疹减轻,1月后皮疹消退。例2接受rhTNFR:Fc 50 mg皮下注射、1次/周,治疗4次后左下肢出现散在的黄豆大小红色丘疹,此后丘疹面积逐渐增大并出现脱屑,考虑为rhTNFR:Fc所致。停用该药,给予糖皮质激素和其他抗风湿药物及补钙等治疗,14 d后丘疹基本消退。
Two patients(patient 1,a 59‐year‐old female;patient 2,a 67‐year‐old female)were treated with recombinant human tumor necrosis factor‐αreceptorⅡ:IgG Fc fusion protein(rhTNFR:FC)due to axial spondyloarthritis and rheumatoid arthritis,respectively.Patient 1 received subcutaneous injection of rhTNFR:FC 50 mg once a week.After 3 times of treatment,the patient developed miliary red papules on both upper arms,accompanied by pruritus.The patient stopped rhTNFR:FC by herself and the papules were relieved.Two weeks later,RhTNFR:FC was used again,the red papules on bilateral upper arms recurred and were aggravated,and miliary red papules on both shoulder and back and edematous erythema on left ankle were observed.Drug eruption due to rhTNFR:FC was considered.Then rhTNFR:FC was stopped.The drug eruption was relieved after 10 days of anti‐allergic treatments and subsided 1 month later.Patient 2 received subcutaneous injection of rhTNFR:FC 50 mg once a week.After 4 times of treatment,scattered bean‐size red papules appeared on her left lower limb,which gradually enlarged,accompanied by desquamation.Drug eruption due to rhTNFR:FC was considered.Then rhTNFR:FC was stopped and glucocorticoid,other anti‐rheumatic drugs,and calcium supplement were given.Fourteen days later,the papule were almost disappeared.
作者
吴桂英
孙志强
乌日力嘎
王勇
白丽杰
Wu Guiying;Sun Zhiqiang;Wuriliga;Wang Yong;Bai Lijie(Department of Rheumatology and Immunology,the Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot 010050,China;Department of Dermatology,the Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot 010050,China)
出处
《药物不良反应杂志》
CSCD
2022年第2期96-98,共3页
Adverse Drug Reactions Journal
关键词
药疹
关节炎
类风湿
椎关节炎
重组人Ⅱ型肿瘤坏死因子受体-抗体融合蛋白
Drug eruptions
Arthritis,rheumatoid
Spondylarthritis
Recombinant human tumor necrosis factor‐αreceptorⅡ:IgG Fc fusion protein
