摘要
目的:考察我国围手术期应激性溃疡预防用药的相关情况。方法:检索中国知网、万方数据库、维普数据库和中国生物医学文献数据库中涉及围手术期预防应激性溃疡情况调查的临床研究,检索时间为不同期刊的创刊时间至2020年12月3日,阅读全文,对纳入的研究进行相关资料提取和统计分析。结果:共纳入36项研究,涉及22624例外科患者,其中进行应激性溃疡预防用药的患者共17865例。18项研究考察了应激性溃疡预防用药率,其中应激性溃疡预防用药率为49.29%(4539/9208);29项研究评价了应激性溃疡预防用药是否符合相关指征,无指征预防用药率为51.90%(6758/13020);19项研究评价了应激性溃疡预防用药的合理性,不合理用药率为72.68%(8329/11460)。结论:我国围手术期预防应激性溃疡存在大量过度预防用药的情况,并且存在用药不合理现象。
OBJECTIVE:To investigate the relevant situation of prophylactic medication of stress ulcer during perioperative period in China.METHODS:CNKI,Wanfang Data,VIP database and CBM were retrieved to collect the clinical studies related to prophylactic medication for stress ulcer during perioperative period.The retrieval time was from the establishment of different journals to Dec.3 rd,2020.The relevant information was extracted and statistically analyzed for the included studies after reading the full text.RESULTS:A total of 36 studies were enrolled,including 22624 surgical patients,of which totally 17865 patients underwent stress ulcer prophylaxis.The rate of prophylactic medication for stress ulcer was 49.29%(4539/9208)in 18 studies.Twenty-nine studies evaluated stress ulcer prophylaxis for relevant indications,with an unindicated prophylaxis rate of 51.90%(6758/13020).Nineteen studies evaluated the rationality of prophylactic medication for stress ulcer,and the irrational medication rate was 72.68%(8329/11460).CONCLUSIONS:There is a large amount of over-prophylaxis in the prevention of stress ulcers in the perioperative period in China,with irrational drug use phenomenon.
作者
李哲
李丹丹
温爱萍
沈素
LI Zhe;LI Dandan;WEN Aiping;SHEN Su(Dept.of Pharmacy,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)
出处
《中国医院用药评价与分析》
2022年第2期232-236,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
北京市医院管理局消化内科学科协同发展中心专项经费资助项目(No.XXZ06)。
