摘要
目的探讨儿童氟斑牙发生风险与骨代谢相关指标之间的关系。方法于2017年4-5月选取河南省开封市通许县4所小学作为调查地点,整群抽样法抽取学校7~12岁儿童共502名,采集晨尿和空腹静脉血,利用氟离子选择电极法测定尿氟,全自动生化分析仪测定血清钙、磷、碱性磷酸酶(ALP)、骨特异性碱性磷酸酶(BALP)、骨钙素(OC)、降钙素(CT)、甲状旁腺激素(PTH)水平。Dean法评估儿童氟斑牙患病情况,并根据结果分为氟斑牙组(n=173)和对照组(n=329)。采用logistic回归分析儿童氟斑牙发生风险与骨代谢相关指标之间的关系。结果与对照组比较,氟斑牙组儿童血清磷、OC水平均低于对照组(mmol/L:1.54±0.19比1.58±0.21;ng/ml:11.59±5.22比12.78±5.88,P均<0.05)。logistic回归分析显示,血清OC水平对氟斑牙发生风险有影响[比值比(OR)=0.96,95%置信区间(CI):0.92~0.99,P<0.05]。骨代谢相关指标对氟斑牙发生风险的贡献度由大到小分别为血清OC(36.34%)、磷(25.89%)、BALP(13.16%)、PTH(9.73%)、钙(9.44%)、CT(3.72%)和ALP水平(1.72%)。结论儿童氟斑牙的发生与骨代谢指标变化有关,OC在氟斑牙的发生中发挥重要作用。
Objective This study was aimed to explore the associations between the risk of dental fluorosis and the serum biomarkers of bone metabolism in children.Methods A total of 502 children aged 7-12 years were selected by cluster sampling from 4 primary schools in Tongxu County,Kaifeng City,Henan Province from April to May 2017.Morning urine and fasting peripheral blood samples were collected from each participant.Urinary fluoride concentration was determined by fluoride ion selective electrode method.Serum calcium,phosphorus,alkaline phosphatase(ALP),bone-specific alkaline phosphatase(BALP),osteocalcin(OC),calcitonin(CT)and parathyroid hormone(PTH)levels were measured using an automatic biochemical analyzer.Dean method was used to evaluate the prevalence of dental fluorosis in children,and the participants were divided into dental fluorosis group(n=173)and control group(n=329)after being diagnosed by trained physicians for their dental fluorosis.The associations between the risk of dental fluorosis and the serum biomarkers of bone metabolism in children were analyzed by logistic regression.Results The levels of serum phosphorus(mmol/L:1.54±0.19 vs 1.58±0.21)and OC(ng/ml:11.59±5.22 vs 12.78±5.88)in children in dental fluorosis group were significantly lower than those in children in control group(P<0.05).Logistic regression analysis showed that serum OC level affected the risk of dental fluorosis[odds ratio(OR)=0.96,95%confidence interval(CI):0.92-0.99,P<0.05].The relative contribution of the biomarkers of bone metabolism to the risk of dental fluorosis in descending order were serum OC(36.34%),phosphorus(25.89%),BALP(13.16%),PTH(9.73%),calcium(9.44%),CT(3.72%)and ALP(1.72%).Conclusions The prevalence of dental fluorosis in children is related to the changes of serum biomarkers of bone metabolism.Serum OC plays an important role in the occurrence of dental fluorosis.
作者
候香博
周郭育
高明慧
黄辉
席豫
李志远
余方方
朱静媛
巴月
Hou Xiangbo;Zhou Guoyu;Gao Minghui;Huang Hui;Xi Yu;Li Zhiyuan;Yu Fangfang;Zhu Jingyuan;Ba Yue(Department of Environmental Health,School of Public Health,Zhengzhou University,Zhengzhou 450001,China;Yellow River Institute for Ecological Protection&Regional Coordinated Development,Zhengzhou University,Zhengzhou 450001,China;Department of Endemic Disease,Kaifeng Municipal Center for Disease Control and Prevention of Henan Province,Kaifeng 475004,China)
出处
《中华地方病学杂志》
CAS
北大核心
2022年第2期144-148,共5页
Chinese Journal of Endemiology
基金
国家自然科学基金(81972981、81673116)
河南省高等学校重点科研项目(21A330006)。
关键词
氟中毒
牙
儿童
骨钙素
Fluorosis,dental
Child
Osteocalcin
