摘要
目的探究非洛地平缓释片治疗高血压的达标率及安全性。方法选择2018年1月至2021年1月我院收治的120例原发性高血压患者作为研究对象,依据单双号将患者随机分为常规组与观察组,各60例。常规组给予常规高血压治疗,观察组在常规高血压治疗的基础上给予非洛地平缓释片治疗。比较两组患者的血压控制情况、动态血压、心率(HR)、总胆固醇(TC)、血糖(BS)、内皮素-1(ET-1)、一氧化氮(NO)、细胞间黏附分子-1(ICAM-1)水平和药物不良反应发生情况。结果观察组的血压控制总达标率高于常规组,差异具有统计学意义(P<0.05)。治疗后,两组的24 h平均血压、白昼平均血压、夜间平均血压均降低,且观察组低于常规组,差异具有统计学意义(P<0.05);治疗后,观察组的24 h HR低于常规组,差异具有统计学意义(P<0.05);治疗后,两组的TC、BS水平比较,差异无统计学意义(P>0.05)。治疗后,两组的ET-1、ICAM-1水平均降低,NO水平均升高,且观察组优于常规组,差异具有统计学意义(P<0.05)。观察组的药物不良反应总发生率低于常规组,差异具有统计学意义(P<0.05)。结论非洛地平缓释片能够显著提高高血压患者的血压控制达标率,改善动态血压及血管内皮功能指标水平,降低药物不良反应发生率,值得临床推广应用。
Objective To explore the compliance rate and safety of felodipine sustained release tablets in the treatment of hypertension.Methods A total of 120 patients with essential hypertension treated in our hospital from January 2018 to January 2021 were selected as the research objects.The patients were randomly divided into routine group and observation group according to single and double numbers,with 60 cases in each group.The routine group was given routine hypertension treatment,and the observation group was given felodipine sustained release tablets on the basis of routine hypertension treatment.The blood pressure control,ambulatory blood pressure,heart rate(HR),total cholesterol(TC),blood glucose(BS),endothelin-1(ET-1),nitric oxide(NO),intercellular adhesion molecule-1(ICAM-1)levels and adverse drug reactions were compared between the two groups.Results The total compliance rate of blood pressure control in the observation group was higher than that in the routine group,and the difference was statistically significant(P<0.05).After treatment,the 24 h mean blood pressure,daytime mean blood pressure and nighttime mean blood pressure in the two groups decreased,those in the observation group were lower than the routine group,and the differences were statistically significant(P<0.05);after treatment,the 24 h HR in the observation group was lower than that in the routine group,and the difference was statistically significant(P<0.05);after treatment,there were no significant differences in the levels of TC and BS between the two groups(P>0.05).After treatment,the levels of ET-1 and ICAM-1 decreased and NO increased in the two groups,those in the observation group were better than the routine group,and the differences were statistically significant(P<0.05).The total incidence of adverse drug reactions in the observation group was lower than that in the routine group,and the difference was statistically significant(P<0.05).Conclusion Felodipine sustained release tablets can significantly improve the compliance rate of blood pressure control in patients with hypertension,improve the ambulatory blood pressure and vascular endothelial function level,and reduce the incidence of adverse drug reactions,which is worthy of clinical promotion and application.
作者
张钰
闫鑫辉
赵振平
王丽娜
ZHANG Yu;YAN Xinhui;ZHAO Zhenping;WANG Lina(Cardiovascular Medicine Department,Baoji High-tech Hospital,Baoji 721000;Cardiovascular Medicine Department,Shenmu Hospital,Shenmu 719300,China)
出处
《临床医学研究与实践》
2022年第8期18-21,共4页
Clinical Research and Practice
基金
国家重点研发计划“国家质量基础的共性技术研究与应用”重点专项子课题(No.2019YFF0216502)。
关键词
非洛地平缓释片
高血压
达标率
felodipine sustained release tablets
hypertension
compliance rate
