摘要
目的探讨脉冲射频刺激联合普瑞巴林治疗带状疱疹后遗三叉神经痛的临床效果,为临床治疗该病提供参考依据。方法选取我科室于2017年2月至2020年2月收治的358例带状疱疹后遗三叉神经疼痛者为研究对象,以随机数字表法将其分为对照组和观察组,各179例。对照组给予普瑞巴林治疗,观察组给予脉冲射频刺激联合普瑞巴林治疗。比较两组的疼痛程度、机体神经肽水平、生活质量及治疗过程中的不良反应发生情况。结果治疗后1、2、3、4周,观察组的VAS评分均明显低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的SP、CGRP水平明显低于对照组,β-EP水平明显高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的生理机能、生理职能、躯体疼痛、一般健康状况、精力、社会功能、情感职能、精神健康评分均较治疗前明显升高,且观察组高于对照组,差异具有统计学意义(P<0.05)。两组患者治疗过程中的不良反应总发生率比较,差异无统计学意义(P>0.05)。结论脉冲射频刺激联合普瑞巴林应用于带状疱疹后遗三叉神经痛的治疗中,可改善患者体内的神经肽水平,迅速缓解疼痛,提升生活质量,且不增加不良反应,安全性好,值得推广。
Objective To investigate the clinical effect of pulsed radiofrequency stimulation combined with pregabalin in the treatment of postherpetic trigeminal neuralgia,and to provide reference basis for clinical treatment of the disease.Methods A total of 358 patients with postherpetic trigeminal neuralgia treated in our department from February 2017 to February 2020 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 179 cases in each group.The control group was treated with pregabalin,and the observation group was treated with pulsed radiofrequency stimulation combined with pregabalin.The pain degree,neuropeptide level of body,quality of life and occurrence of adverse reactions during treatment were compared between the two groups.Results At 1,2,3 and 4 weeks after treatment,the VAS score in the observation group was significantly lower than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of SP and CGRP in the observation group were significantly lower than those in the control group,the level ofβ-EP was significantly higher than that in the control group,and the differences were statistically significant(P<0.05).After treatment,the scores of physical functioning,role-physical,bodily pain,general health,vitality,social functioning,role-emotional and mental health in the two groups were significantly higher than those before treatment,and those in the observation group were higher than the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions during treatment between the two groups(P>0.05).Conclusion Pulsed radiofrequency stimulation combined with pregabalin in the treatment of postherpetic trigeminal neuralgia can improve the level of neuropeptides in patients,quickly relieve pain and improve the quality of life without increasing adverse reactions,has good safety,which is worth popularizing.
作者
朱建设
连亚军
ZHU Jianshe;LIAN Yajun(Neurology Department,Shangshui People's Hospital,Zhoukou 466100;Neurology Department,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《临床医学研究与实践》
2022年第8期36-39,共4页
Clinical Research and Practice
