摘要
为了探讨线粒体延伸因子TEFM在弥漫性大B细胞淋巴瘤DLBCL中的表达,初步研究其表达与DLBCL患者的临床特征及预后的关系,从数据库中下载关于DLBCL患者TEFM mRNA二代测序数据及临床病理资料,分析TEFM转录水平与临床病理参数的相关性及其预后价值。结果显示TEFM在DLBCL组织中均较正常淋巴组织显著高表达,mRNA表达水平与预后无显著相关性(P>0.05),其表达水平在DLBCL患者不同病理分期中的表达无显著差异(P>0.05)。多因素分析结果显示,TEFM表达水平和种族是影响DLBCL患者预后的独立因素。TEFM基因表达水平与SUZ12P1、SNHG10、METTL17和BCS1L基因表达水平呈正相关(P<0.05)。数据库中荟萃了TEFM mRNA在DLBCL组织中表达的相关信息,证实TEFM mRNA在DLBCL组织中呈高表达,但其表达水平与DLBCL患者预后无明显关联。
To explore the expression of Mitochondrial transcription elongation factor(TEFM)in diffuse large B cell lymphoma(DLBCL)based on the cancer genome atlas(TCGA)and Oncomine datasets.Furthermore,to elucidate the correlation between the expression of TEFM mRNA and the clinicopathological parameters of DLBCL.The expression data of TEFM and its clinical information in DLBCL were downloaded from TCGA and Oncomine database.Then the relationship between the expression of TEFM and clinicopathological characteristics and the prognostic value of TEFM were analyzed.The TEFM mRNA expression level in DLBCL was higher than that in normal tissues.Moreover,the survival rate of DLBCL patients in GEPIA database was analyzed.There were no differences about the survival time between the patients with low TEFM expression and high TEFM expression.There also were no significant differences about the mRNA expression levels of TEFM in different pathological stages in DLBCL patients(P>0.05).Multi-factor analysis showed that TEFM expression levels and ethnicity were independent factor to the prognosis of DLBCL patients.The mRNA expression levels of TEFM were positively associated with the SUZ12P1,SNHG10,METTL17 and BCS1L.The database contained information on the expression of TEFM gene in DLBCL,confirming that TEFM gene was highly expressed in DLBCL tissues.However,the expression of TEFM mRNA was not significantly associated with the prognosis of patients with DLBCL.
作者
何冰
梅雯
孙晓梅
孙如丽
赵楠
温莺璇
熊伟
赵一
HE Bing;MEI Wen;SUN Xiao-mei;SUN Ru-li;ZHAO Nan;WEN Yin-xuan;XIONG Wei;ZHAO Yi(Department of Pathology,Chuxiong People’s Hospital,Chuxiong,Yunnan 675000,China;College of Basic Medical Sciences,Dali University,Dali,Yunnan 671000,China)
出处
《井冈山大学学报（自然科学版）》
2022年第2期48-55,共8页
Journal of Jinggangshan University (Natural Science)
基金
国家自然科学基金项目(No.81560458)
云南省教育厅科学研究基金项目(2021J0376)。
