摘要
脊髓损伤是一种严重的中枢神经系统疾病,会引起一系列复杂的病理生理学变化,激活包括Notch信号在内的多种信号通路。研究证实Notch信号通路的激活不利于脊髓损伤后神经修复和症状改善,其机制包括抑制神经元分化和轴突再生,促进反应性星形胶质细胞增生,促进M1型巨噬细胞极化和促炎因子的释放,抑制新生血管的生成。因此,以抑制Notch信号为靶点治疗脊髓损伤已成为一种有希望的治疗策略。近年来,一些研究人员通过药物、细胞移植或转基因技术来调控Notch信号,能够促进脊髓损伤后神经功能恢复,从而为脊髓损伤的治疗提供新的治疗方法。本文将对Notch信号通路在脊髓损伤中的作用机制加以总结,同时归纳近年来通过干预Notch信号通路来治疗脊髓损伤的研究进展,为进一步探索脊髓损伤治疗的新策略提供研究思路。
Spinal cord injury is a severe central nervous system disease,which will cause a series of complex pathophysiological changes and activate a variety of signaling pathways including Notch signaling.Studies have evidenced that activation of the Notch signaling pathway is not conducive to nerve repair and symptom improvement after spinal cord injury.Its mechanisms include inhibiting neuronal differentiation and axon regeneration,promoting reactive astrocyte proliferation,promoting M1 macrophage polarization and the release of proinflammatory factors,and inhibiting angiogenesis.Therefore,it has become a promising therapeutic strategy to inhibit Notch signal as a target in the treatment of spinal cord injury.In recent years,some researchers have used drugs,cell transplantation or genetic modification to regulate Notch signaling,which can promote the recovery of nerve function after spinal cord injury,thereby providing new treatment strategies for the treatment of spinal cord injury.This article will summarize the mechanism of Notch signaling pathway in spinal cord injury,and at the same time review the research progress in the treatment of spinal cord injury by modulating Notch signaling pathway in recent years,so as to provide new research ideas for further exploring new strategies for spinal cord injury.
作者
李京
李嘉熙
贺西京
陈华佑
赵航
LI Jing;LI Jia-xi;HE Xi-jing;CHEN Hua-you;ZHAO Hang(不详;The Second Department of Orthopaedics,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710004,Shaanxi,China)
出处
《中国骨伤》
CAS
CSCD
2022年第2期194-198,共5页
China Journal of Orthopaedics and Traumatology
基金
国家自然科学基金项目(编号:81771349)。
