摘要
目的分析瑞舒伐他汀钙片联合多奈哌齐治疗脑梗死并血管性痴呆(VD)的效果和安全性。方法抽取2019年1月至2021年1月南阳市中心医院收治的脑梗死并VD患者96例,按随机数字表法分为联合组与单一组,每组48例。单一组采用多奈哌齐治疗,联合组给予瑞舒伐他汀钙片联合多奈哌齐进行治疗。比较两组的治疗效果及治疗前后痴呆评分[长谷川痴呆量表(HDS)、简易智能精神状态检查量表(MMSE)]、事件相关电位(ERP)参数、炎性因子[白细胞介素-1β(IL-1β)、C反应蛋白(CRP)]水平、氧化应激[超氧化物歧化酶(SOD)、丙二醛(MDA)]及血管内皮功能[一氧化氮(NO)、内皮素-1(ET-1)],比较两组不良反应发生率。结果联合组总有效率(95.83%,46/48)高于单一组(83.33%,40/48),P<0.05。治疗后,联合组HDS、MMSE评分均高于单一组(P均<0.05)。治疗后,联合组潜伏期N2值低于单一组,波幅P3值高于单一组(P<0.05)。治疗后,联合组IL-1β、CRP水平均低于单一组(P均<0.05);SOD高于单一组,MDA低于单一组(P<0.05);NO水平高于单一组,ET-1水平低单一组(P<0.05)。两组不良反应发生率比较差异未见统计学意义(P>0.05)。结论多奈哌齐联合瑞舒伐他汀钙片治疗脑梗死并VD,可调节ERP参数,改善患者的炎性状态、氧化应激水平和血管内皮功能,减轻痴呆严重程度,提高临床效果,且具有安全性。
Objective To analyze the efficacy and safety of rosuvastatin calcium tablets and donepezil in the treatment of cerebral infarction(CI)complicated by vascular dementia(VD).Methods A total of 96 patients with CI complicated by VD treated in Nanyang Central Hospital from January 2019 to January 2021 were selected.And they were divided into combined group and single group by random number table method,with 48 cases in each group.The single group was given donepezil,while the combined group was given rosuvastatin calcium tablets combined with donepezil.The treatment effects of the two groups were compared;the dementia scores assessed by Hasegawa’s dementia scale(HDS)and mini mental state examination(MMSE),parameters of event-related potential(ERP),inflammatory factors,including interleukin-1β(IL-1β),C-reactive protein(CRP),oxidative stress,including superoxide dismutase(SOD),malondialdehyde(MDA),and vascular endothelial function,including nitric oxide(NO),endothelin-1(ET-1)before and after treatment were compared between the two groups.The incidence of adverse reactions of the two groups were compared.Results The total effective rate of the combined group(95.83%,46/48)was higher than that of the single group(83.33%,40/48),P<0.05.After treatment,HDS and MMSE scores in the combined group were higher than those in the single group(all P<0.05).After treatment,the latency N2 value of the combined group was lower than that of the single group,and the amplitude P3 value was higher than that of the single group(P<0.05).After treatment,the levels of IL-1βand CRP in the combined group were lower than those in the single group(all P<0.05).After treatment,the level of SOD of the combined group was higher than that of the single group,and MDA was lower than that of the single group(P<0.05).After treatment,the level of NO of the combined group was higher than that of the single group,the level of ET-1 was lower than that of the single group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions Rosuvastatin calcium tablets combined with donepezil for CI and VD can regulate ERP parameters,improve the inflammatory state,oxidative stress levels and vascular endothelial function,reduce the severity of dementia,improve tahe clinical effect,with high safety.
作者
黄景贺
贾贺
陈艳芳
Huang Jinghe;Jia He;Chen Yanfang(Department of Neurology,Nanyang Central Hospital,Nanyang 473000,China;Department of Geriatrics,the Second Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,Chin)
出处
《中国实用医刊》
2022年第1期98-101,共4页
Chinese Journal of Practical Medicine
关键词
脑梗死
血管性痴呆
多奈哌齐
瑞舒伐他汀钙片
Cerebral infarction
Vascular dementia
Donepezil
Rosuvastatin calcium tablets
