摘要
T细胞免疫球蛋白和免疫受体酪氨酸抑制性基序结构域(TIGIT)是主要表达于活化的T细胞、调节性T细胞(Tregs)和自然杀伤(NK)细胞表面的免疫抑制性受体。最近的研究表明TIGIT可通过与癌细胞或病原体感染细胞表面的多种配体相结合,直接抑制免疫细胞的活化、增殖或间接诱导免疫抑制性因子的产生。用TIGIT单克隆抗体干预可明显改善免疫细胞的功能,有望成为类似于PD-1的全新治疗靶点。因此,阐明TIGIT在感染性免疫应答中发挥作用的具体机制将有助于揭示多种疾病中免疫细胞功能低下的原因,并为病原体感染的治疗提供新方案。本文简要介绍TIGIT分子的结构与功能,并且就TIGIT在细菌、病毒和寄生虫感染中发挥的作用及作用机制进行了系统综述。
T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain(TIGIT)is a immune inhibitory receptor,mainly expressed on activated T cells,regulatory T cell(Tregs)and natural killer(NK)cells.Recent studies have shown that TIGIT can directly inhibit the activation and proliferation of immune cells or indirectly induce the production of immunosuppressive factors by binding to a variety of ligands on the surface of cancer cells or pathogen-infected cells.Intervention with TIGIT monoclonal antibody can significantly improve the function of immune cells,which is expected to become a new therapeutic target similar to PD-1.Therefore,elucidating the specific mechanism of the role of TIGIT in infectious immune response will help to reveal the causes of low immune cell function in many diseases and provide a new scheme for the treatment of pathogen infection.This paper briefly introduces the structure and function of TIGIT,and systematically reviews the role and mechanism of TIGIT in bacterial,viral and parasite infection.
作者
李浩然
张富强
张振超
李祥瑞(指导)
王帅(指导)
LI Haoran;ZHANG Fuqiang;ZHANG Zhenchao;LI Xiangrui;WANG Shuai(Department of Pathogenic Biology,School of Basic Medical Sciences,Xinxiang Medical University,Xinxiang 453003,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2022年第5期632-637,共6页
Chinese Journal of Immunology
基金
国家自然科学基金项目(81702025)
河南省科技攻关计划项目(212102310749)
河南省高等学校重点科研项目(22A310004)资助。
