摘要
目的分析金水宝胶囊联合坎地沙坦酯片在早期糖尿病肾病(DN)治疗中的应用效果。方法选择2019年6月至2020年6月于朝阳市第二医院就诊的62例早期DN患者作为本研究的观察对象,用掷硬币的方式将62例患者分为对照组和观察组,每组各31例。对照组单一使用坎地沙坦酯片治疗,观察组则在其基础上加入金水宝胶囊进行治疗。比较两组24 h尿蛋白定量、尿白蛋白排泄率(UAE)、血肌酐(Scr)、血尿素氮(BUN)、血清钾(K^(+))、内生肌酐清除率(Ccr)。结果治疗后,观察组24 h尿蛋白定量为(0.14±0.04)g/24 h,低于对照组的(0.32±0.07)g/24 h(P<0.05);治疗后观察组UAE为(64.37±6.31)μg/min,低于对照组的(76.42±7.51)μg/min(P<0.05);治疗后观察组的Scr为(98.43±10.15)μmol/L,低于对照组的(112.31±13.01)μmol/L,BUN为(4.67±1.09)mmol/L,低于对照组的(6.79±1.36)mmol/L,Ccr为(75.31±9.11)ml/min,高于对照组的(86.76±10.02)ml/min,K^(+)为(3.20±0.47)mmol/L,低于对照组的(4.82±0.84)mmol/L,差异均有统计学意义(P<0.05)。结论坎地沙坦酯片与金水宝胶囊应用于早期DN治疗,能够有效改善患者的肾功能,控制尿蛋白排泄,具有明显的临床效果,值得进一步推广使用。
Objective To analyze the application effect of Jinshuibao capsule combined with candesartan cilexetil tablet in the treatment of early diabetic nephropathy.Methods A total of 62 patients with early DN treated in the Second Hospital of Chaoyang form June 2019 to June 2020 were selected as research subjects,and were divided into the control group(n=31)and the observation group(n=31)by tossing a coin.Only candesartan cilexetil tablet was given to the control group,and Jinshuibao capsule was given to the observation group on the basis of the control group.The 24-hour urine quantitative protein,urinary albumin excretion rates(UAE),serum creatinine(Scr),blood urea nitrogen(BUN),serum potassium(K^(+)),and endogenous creatinine clearance rates(Ccr)were compared in the two groups.Results After treatment,the 24-hour urine quantitative protein in the observation group(0.14±0.04)g/24 h was lower than that in the control group(0.32±0.07)g/24 h(P<0.05);the UAE in the observation group(64.37±6.31)μg/min was lower than that in the control group(76.42±7.51)μg/min(P<0.05);the Scr in the observation group(98.43±10.15)μmol/L was lower than that in the control group(112.31±13.01)μmol/L,the BUN in the observation group(4.67±1.09)mmol/L was lower than that in the control group(6.79±1.36)mmol/L,the Ccr in the observation group(75.31±9.11)ml/min was higher than that in the control group(86.76±10.02)ml/min,and the K^(+) in the observation group(3.20±0.47)mmol/L was lower than that in the control group(4.82±0.84)mmol/L,with statistically significant differences(P<0.05).Conclusion The application of Jinshuibao capsule combined with candesartan cilexetil tablet in the treatment of early diabetic nephropathy can effectively improve the renal function of patients and control urine albumin excretion,which has obvious clinical effect and is worthy of further promotion.
作者
于洪娟
YU Hongjuan(Department of Nephrology,the Second Hospital of Chaoyang in Liaoning Province,Chaoyang 122000,China)
出处
《中国现代医生》
2022年第5期34-37,共4页
China Modern Doctor
关键词
金水宝胶囊
坎地沙坦酯片
早期糖尿病肾病
肾功能
Jinshuibao capsule
Candesartan cilexetil tablet
Early diabetic nephropathy
Renal function
