摘要
目的探讨药物热的临床特点,为判断和治疗药物热提供参考。方法回顾性收集恩施州各医疗卫生单位2015年1月1日至2019年12月31日上报国家药品不良反应监测系统发生药物热相关性报告,对筛选出的283例报告进行用药情况与临床表现汇总分析。结果致热药物主要是中药制剂78例(27.56%)和抗菌药物64例(22.61%)。主要给药途径是静脉滴注,共249例(87.99%)。大部分药物热伴发其他症状,其中伴寒战、畏寒199例(42.98%),伴皮损40例(8.64%)。85.87%的药物热出现在用药7 d内,但最晚可于用药后28 d出现。269例(94.70%)停药后当天体温缓解。结论我州中药制剂和抗菌药为主要致热药物,药物热常伴寒战,但仅少数伴发皮损等过敏症状。
Objective To explore the characteristics of drug fever and provide reference for related diagnosis and treatment.Methods Cases of drug fever reported by health institutions in Enshi Prefecture from January 1,2015 to December 31,2019 to the national adverse drug reaction detection system were retrospectively collected.A total of 283 cases were screened and analyzed.Results Seventy-nine of these cases(27.92%)were caused by traditional Chinese medicine,and 64(22.61%)by antibiotics.The main route of administration was intravenous injection(249 cases,87.99%).Most of these cases were accompanied by other symptoms,199 of which were chills(46.28%)and 40 were skin damage(9.30%).Drug fever in most(85.87%)of the cases occurred within 7 days of administration,but it could occur as late as 28 days after administration.268 of these cases(94.70%)had temperature remission soon after drug withdrawal.Conclusion Traditional Chinese medicine and antibiotics are the drugs mainly responsible for drug fever in Enshi prefecture.Patients with drug fever often have chills,and only a few have such allergic symptoms as skin lesions.
作者
刘娟
张晶
杨艳玲
王银辉
LIU Juan;ZHANG Jing;YANG Yanling;WANG Yinhui(Department of Clinical Pharmacy,the Central Hospital of Enshi Tujia&Miao Autonomous Prefecture,Enshi Hubei 445000,China)
出处
《中国药物警戒》
2022年第3期328-332,共5页
Chinese Journal of Pharmacovigilance
关键词
药物热
药品不良反应
发热
drug fever
adverse drug reaction
fever
