摘要
目的观察清热化瘀解毒方用于临床治疗脓毒症患者的效果。方法采取随机数字表法,将40例脓毒症患者分为治疗组和对照组,每组分别为20例。2组均予抗感染,维护器官功能等西医常规治疗,治疗组加用清热化瘀解毒方辅助治疗。2组患者的治疗疗程均为1周。治疗后,比较患者治疗前后及2组间白细胞(WBC)、中性粒细胞计数/淋巴细胞计数的比值(NLR)、C-反应蛋白(CRP)以及血清降钙素原(PCT),急性生理和慢性健康评分(APACHEⅡ),序贯器官衰竭评分(SOFA),临床疗效28d病死率。结果经治疗后,2组患者WBC、NLR值、CRP、PCT,APACHEⅡ评分及SOFA评分均较治疗前明显下降(P<0.05),但治疗组下降更显著(P<0.05);治疗组总有效率85%显著高于对照组的65%(P<0.05);患者28 d病死率为25%,对照组28 d病死率为35%,治疗组低于对照组(P<0.05)。结论临床上使用清热化瘀解毒方治疗脓毒症能够抑制炎症反应,改善患者的临床症状,控制疾病进展,减少其病死率。
Objective: To observe the effect of Qingre Huayu Jiedu Decoction in the clinical treatment of patients with sepsis. Methods: By random number table method, 40 patients with sepsis were divided into a treatment group and a control group, 20 cases per group. Both groups were treated with conventional western medicine such as anti-infection and maintenance of organ function, and the treatment group was additionally treated with Qingre Huayu Jiedu Decoction. The patients of the two groups were given one-week course treatment. After treatment, the white blood cells(WBC), neutrophil count/lymphocyte count ratio(NLR), C-reactive protein(CRP) and serum procalcitonin(PCT) as well as the acute physiology and chronic health score(APACHE Ⅱ), sequential organ failure score(SOFA), clinical efficacy and 28-day mortality were compared between the two groups before and after treatment. Results: After treatment, the WBC, NLR, CRP, PCT, APACHE Ⅱ scores and SOFA scores of the two groups were significantly decreased compared with those before treatment(P<0.05), but the decrease in the treatment group was more significant(P<0.05). The effective rate of the treatment group was 85%, significantly higher than that(65%) of the control group(P<0.05). The 28-day mortality rate of the treatment group was 25%, and the 28-day mortality rate of the control group was 35%. The rate of the treatment group was lower than that of the control group(P<0.05). Conclusion: Clinically, Qingre Huayu Jiedu Decoction in the treatment of sepsis can inhibit the inflammatory response, improve the clinical symptoms of patients, control the progression of the disease and reduce the mortality rate.
作者
宋琳
李荣荣
倪海滨
SONG Lin;LI Rong-rong;NI Hai-bin(Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing 210009,China)
出处
《云南中医中药杂志》
2022年第3期48-52,共5页
Yunnan Journal of Traditional Chinese Medicine and Materia Medica
基金
国家自然科学基金项目(81673932)
江苏省卫生计生委科研课题(Z201605)。
关键词
脓毒症
清热化瘀解毒方
中西医结合
Sepsis
Qingre Huayu Jiedu Decoction
Integration Of Traditional Chinese and Western Medicine
