摘要
目的探讨血清妊娠相关血浆蛋白-A(PAPP-A)、胎盘生长因子受体(PLGF)、抑制素A(INH-A)与妊娠肝内胆汁淤积症(ICP)严重程度及胎儿生长受限(FGR)的关系。方法将该院2018年1月至2020年1月收治的113例合并ICP的孕妇(ICP组)及50例健康孕妇(对照组)纳为研究对象,分别比较ICP组与对照组及不同病情ICP患者血清PAPP-A、PLGF及INH-A水平;分析ICP患者血清PAPP-A、PLGF及INH-A水平与其总胆汁酸(TBA)、丙氨酸氨基转移酶(ALT)及天门冬氨酸氨基转移酶(AST)水平的相关性。统计ICP患者中合并FGR情况,分析其与血清PAPP-A、PLGF及INH-A水平间的关系。结果ICP组血清PAPP-A、PLGF水平低于对照组(P<0.05),INH-A水平高于对照组(P<0.05);重度ICP组血清PAPP-A、PLGF水平低于轻度ICP组(P<0.05),INH-A水平高于轻度ICP组(P<0.05);ICP组肝功能指标TBA、ALT及AST水平均高于对照组(P<0.05),重度ICP组TBA、ALT及AST水平高于轻度ICP组(P<0.05)。相关性分析结果显示,ICP患者血清PAPP-A、PLGF与TBA水平呈负相关(P<0.05),INH-A与TBA水平呈正相关(P<0.05)。ICP合并FGR组血清PAPP-A、PLGF水平低于ICP未合并FGR组(P<0.05),INH-A水平高于ICP未合并FGR组(P<0.05)。ICP合并FGR组血清PAPP-A、PLGF水平低于健康妊娠合并FGR组(P<0.05),INH-A水平高于健康妊娠合并FGR组(P<0.05)。结论血清PAPP-A、PLGF及INH-A可能与ICP发生、发展及FGR有关。
Objective To investigate the influence of changes of serum pregnancy-associated plasma protein A(PAPP-A),placental growth factor(PLGF)and inhibin A(INH-A)on the severity of intrahepatic cholestasis of pregnancy(ICP)and fetal growth restriction(FGR).Methods A total of 113 pregnant women with ICP(ICP group)and 50 healthy pregnant women(control group)in our hospital from January 2018 to January 2020 were enrolled.ICP group was further divided into subgroups according to different severity degrees,then the serum levels of PAPP-A,PLGF and INH-A were compared within groups and subgroups.The relationship of serum PAPP-A,PLGF and INH-A levels in ICP women with total bile acid(TBA),alanine aminotransferase(ALT)and aspartate aminotransferase(AST)levels were analyzed.The incidence rate of FGR was recorded in ICP group,and its correlation with serum PAPP-A,PLGF and INH-A levels was analyzed.Results Serum PAPP-A and PLGF levels in ICP group were significantly lower than those in control group(P<0.05),and INH-A level was significantly higher than that in control group(P<0.05).Serum PAPP-A and PLGF levels in severe ICP group were significantly lower than those in mild ICP group(P<0.05),and INH-A level was significantly higher than that in severe ICP group(P<0.05).The liver function indexes TBA,ALT and AST levels of ICP group were significantly higher than those of control group(P<0.05),and the levels of TBA,ALT and AST in severe ICP group were significantly higher than those in mild ICP group(P<0.05).Correlation analysis showed that serum PAPP-A and PLGF were negatively correlated with TBA levels(P<0.05),and INH-A was positively correlated with TBA levels(P<0.05).Serum PAPP-A and PLGF levels in group of ICP patients with FGR were significantly lower than group of ICP patients without FGR(P<0.05),and INH-A was significantly higher than group of ICP patients without FGR(P<0.05).The serum levels of PAPP-A and PLGF in group of ICP with FGR were significantly lower than those in group of normal pregnancy with FGR(P<0.05),and the level of INH-A was significantly higher than that in group of normal pregnancy with FGR(P<0.05).Conclusion Serum PAPP-A,PLGF and INH-A may be related to the occurrence and development of ICP and FGR.
作者
姜方清
苏春芳
秦丽
黄卫东
JIANG Fangqing;SU Chunfang;QIN Li;HUANG Weidong(Department of Obstetrics and Gynecology,Central Hospital of Enshi Tujia and Miao Autonomous Prefecture,Enshi,Hubei 445000,China)
出处
《国际检验医学杂志》
CAS
2022年第6期745-748,共4页
International Journal of Laboratory Medicine
