摘要
目的研究多种自身抗体联合检测方法在自身免疫性疾病诊断中的临床意义。方法本次纳入2019年1月至2020年6月期间在本院接受治疗的116例患者展开研究,所有患者均进行多种自身抗体联合检测,观察自身免疫性疾病的诊断结果。结果多种自身抗体联合检测结果显示,女性的阳性率高于男性,自身免疫性疾病检出率高于非自身免疫性疾病检出率,差异具有统计学意义(P<0.05);SLE、RA、MCTD、SS的检出率分别为82.35%、8.82%、5.88%、2.94%;SLE患者的ANA抗体、抗SSA抗体、抗SSB抗体、dsDNA抗体的阳性率分别为96.43%、89.29%、85.71%、75.00%;RA的抗CCP抗体阳性率为66.67%;MCTD的ANA抗体、抗U1RNP抗体阳性率均为100.00%,SS的ANA抗体阳性率、抗SSA抗体、抗SSB抗体均为100.00%。结论联合检测多种自身抗体可有效检出自身免疫性疾病,对临床诊疗效果的提升具有积极作用。
Objective To study the clinical significance of combined detection of multiple autoantibodies in the diagnosis of autoimmune diseases.Methods 116 patients treated in our hospital from January 2019 to June 2020 were included in the study.All patients were tested with multiple autoantibodies to observe the diagnosis results of autoimmune diseases.Results The results of combined detection of multiple autoantibodies showed that the positive rate of women was higher than that of men,the detection rate of autoimmune diseases was higher than that of non autoimmune diseases,the difference was statistically significant(P<0.05);the detection rates of SLE,RA,MCTD and SS were 82.35%,8.82%,5.88%and 2.94%respectively;the positive rates of ANA antibody,anti SSA antibody,anti SSB antibody and dsDNA antibody were positive in SLE patients The positive rate of anti CCP antibody in RA was 66.67%;the positive rate of ANA antibody and anti U1RNP antibody in MCTD was 100.00%;the positive rate of ANA antibody,anti SSA antibody and anti SSB antibody of SS were 100.00%.Conclusion Combined detection of multiple autoantibodies can effectively detect autoimmune diseases and play a positive role in improving the effect of clinical diagnosis and treatmrnt.
作者
陈振兴
甄广怀
李新亮
马碧蓝
黄秀
CHEN Zhen-xing;ZHEN Guang-huai;LI Xin-liang;MA Bi-lan;HUANG Xiu(Department of Laboratory Medicine,Taishan People's Hospital,Taishan 529200,Guangdong Province,China)
出处
《罕少疾病杂志》
2022年第4期108-109,112,共3页
Journal of Rare and Uncommon Diseases
