摘要
目的:基于生物信息学方法探讨PARVG基因在肾透明细胞癌(KIRC)中的表达及功能。方法:利用多种在线数据库和软件综合分析PARVG基因在KIRC中的预后价值及其相关的调控机制。结果:PARVG基因在KIRC中的表达水平显著高于癌旁正常组织(P<0.05);PARVG基因表达水平与患者不同的肿瘤分期与分级、种族、年龄等临床病理特征直接相关,且其高表达水平提示患者预后不良(P<0.05);PARVG基因的共表达基因有17个,其生物信息学功能主要富集于细胞质膜的形成及完整性的维持、细胞通讯、信号转导等多个方面。结论:PARVG基因在KIRC患者中呈现高表达,可作为KIRC患者诊断、治疗和预后的潜在靶点。
Objective:To investigate the expression and function of PARVG gene in kidney renal clear cell carcinoma(KIRC)based on bioinformatics.Methods:A variety of online databases and software were used to synthetically analyze the prognostic value of PARVG gene in KIRC and its related regulatory mechanism.Results:The expression level of PARVG gene in KIRC was significantly higher than that in normal tissues adjacent to cancer(P<0.05),and the expression level of PARVG gene was directly related to the clinicopathological features of patients with different tumor stages,grades,ethnicities and ages,and its high expression level suggested a poor prognosis(P<0.05).There are 17 co-expressed genes of PARVG gene,and its bioinformatics function is mainly concentrated on the formation and maintenance of plasma membrane,cell communication,signal transduction and so on.Conclusion:PARVG gene is highly expressed in KIRC patients,which can be used as a potential target for diagnosis,treatment and prognosis of KIRC patients.
作者
王立韬
白丽
Wang Litao;Bai Li(Pre-clinical College,Dali,Yunnan 671000,China;Yunnan Key Laboratory of Insect Biomedicine Researchand Development,Dali,Yunnan 671000,China)
出处
《大理大学学报》
2022年第2期39-45,共7页
Journal of Dali University
基金
国家自然科学基金项目(81360319)
云南省中药饮片产业发展专项资金项目(2019-YG-067)。
