摘要
动脉粥样硬化是多种心血管疾病的共同病理基础。越来越多证据表明,炎症在动脉粥样硬化的病理生理过程中发挥重要作用。动脉粥样硬化的发展受先天性免疫与适应性免疫细胞成分调控,且与全身炎症水平相关,多种炎症因子可作为动脉粥样硬化相关心血管疾病的预测指标。同时,一些抗炎治疗的临床试验表明,降低系统性炎症因子水平能够减少心血管事件风险。文章重点阐述了炎症在动脉粥样硬化中的作用、动脉粥样硬化发展中免疫应答的特征,以及目前针对动脉粥样硬化抗炎治疗的临床研究进展,以期为动脉粥样硬化治疗提供新的策略及靶点。
Atherosclerosis is the common pathological basis of various cardiovascular diseases.A large number of evidences indicate that inflammation plays an important role in the pathophysiological process of atherosclerosis.The development of atherosclerosis is regulated by innate and adaptive immune cells,and is closely related to the level of systemic inflammation.A variety of inflammatory factors can be used as predictors of atherosclerosis related cardiovascular diseases,meanwhile,some clinical trials for anti-inflammatory therapy have shown that the risk of cardiovascular events are decreased by reducing the level of systemic inflammatory factors.This article focuses on the role of inflammation,the characteristics of immune response in the development of atherosclerosis,as well as the current progress of clinical research on anti-inflammatory therapy of atherosclerosis,aiming to provide new therapeutic strategies and targets for atherosclerosis.
作者
董亚兰
胡德胜
DONG Yalan;HU Desheng(Department of Integrated Traditional Chinese and Western Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China)
出处
《中国动脉硬化杂志》
CAS
2022年第4期304-312,共9页
Chinese Journal of Arteriosclerosis
基金
国家自然科学基金项目(31770983、81974249)。
关键词
动脉粥样硬化
固有免疫
适应性免疫
动脉三级淋巴组织
抗炎治疗
atherosclerosis
innate immunity
adaptive immunity
artery tertiary lymphoid organs
anti-inflammatory therapy
