摘要
功能性便秘(functional constipation,FC)是在排除其他可能引发继发性便秘产生的原因及便秘型肠易激综合征,以排便困难、排便次数减少或排便不尽感为主要表现的现代常见肠道疾病之一[1]。由于其具体发病机制暂未明确,导致难以根治,症状的反复严重影响了人类的生存质量。近年来,微生态制剂的贡献,使得FC与肠道菌群的认识不断深入,通过重建肠道固有微生态平衡,衍生出新兴的微生态疗法——粪菌移植(fecal microbiota transplantation,FMT)。
The pathogenesis of functional constipation(FC) is currently unclear, which leads to difficult thorough cure. With the further study of intestinal microbiology, the relationship between intestinal flora and FC has been gradually clarified. In addition to the probiotics and prebiotics, a new therapeutic method, fecal microbiota transplantation(FMT) has been developed. The application of FMT in FC is in the development stage, and there is no comprehensive and unified understanding for FMT. Combined with the characteristics of intestinal flora of FC, this article reviews the selection of fecal source, implantation route, transplantation frequency, duration of effect, combination treatment. The purpose is to provide the research direction and references for the application of FMT in FC in the future.
出处
《中国中西医结合消化杂志》
CAS
2022年第3期239-243,共5页
Chinese Journal of Integrated Traditional and Western Medicine on Digestion
基金
国家中医药管理局中医药循证能力建设项目(No:2019XZZX-XH001)
福建中医药大学中医脾胃开放课题(No:X2019027-学科)。
关键词
功能性便秘
粪菌移植
肠道菌群
functional constipation
fecal microbiota transplantation
gut microbiota
