摘要
目的探讨颈三针联合四红祛斑汤对女性气滞血瘀型黄褐斑病人皮损改善及氧化应激反应的影响。方法选取河南宏力医院皮肤科2018年2月至2020年3月女性气滞血瘀型黄褐斑病人126例进行前瞻性随机对照研究,以随机数字表法将病人分为针刺组、中药组、针药联合组,各42例。常规治疗基础上,针刺组给予颈三针,中药组给予四红祛斑汤,针药联合组给予颈三针联合四红祛斑汤,均治疗2个月。对比三组疗效与治疗前后皮损颜色、皮损面积积分、皮肤状态(皮肤弹性、皮肤水分含量)、血清性激素指标[黄体生成素(LH)、促卵泡激素(FSH)、雌二醇(E2)]、氧化应激指标[过氧化氢酶(CAT)、丙二醛(MDA)、超氧化物歧化酶(SOD)]水平。结果针药联合组治疗后总有效率为92.86%,高于针刺组、中药组的71.43%、73.81%(P<0.05);针药联合组治疗后皮损颜色、皮损面积积分分别为(1.16±0.38)分、(1.05±0.34)分,均低于针刺组的(1.57±0.54)分、(1.49±0.50)分、中药组的(1.42±0.49)分、(1.38±0.42)分(P<0.05);针药联合组治疗后皮肤弹性、皮肤水分含量均高于针刺组、中药组(P<0.05);针药联合组治疗后血清LH、FSH、E2水平均低于针刺组、中药组(P<0.05);针药联合组治疗后血清CAT、SOD水平分别为(2.28±0.53)U/mL、(104.48±10.73)U/mL,均高于针刺组的(1.69±0.47)U/mL、(89.52±8.90)U/mL、中药组的(1.85±0.43)U/mL、(93.59±9.26)U/mL,血清MDA水平为(3.52±0.64)mmol/L,低于针刺组的(4.71±0.75)mmol/L、中药组的(4.47±0.69)mmol/L(P<0.05)。结论应用颈三针联合四红祛斑汤治疗女性气滞血瘀型黄褐斑病人可减轻机体氧化应激反应,调节性激素表达,减轻皮损情况,改善皮肤状态,疗效显著。
Objective To investigate the effect of neck three-needle combined with sihong quban decoction on skin lesion improve⁃ment and oxidative stress in female patients with chloasma due to qi stagnation and blood stasis.Methods A prospective randomized controlled study of 126 patients with chloasma with qi stagnation and blood stasis type in Department of Dermatology of Henan Hongli Hospital from February 2018 to March 2020 was selected.The patients were assigned into acupuncture group,Chinese medicine group,and acupuncture and medicine combination group by random number table,with 42 cases in each group.On the basis of routine treat⁃ment,the acupuncture group was given three neck injections,the Chinese medicine group was given sihong quban decoction,and the acupuncture combined group was given neck three needles and sihong quban decoction,all treated for 2 months.The efficacy and skin lesion color,skin lesion area score,skin condition(skin elasticity,skin moisture content),serum sex hormone indexes[luteinizing hor⁃mone(LH),follicle stimulating hormone(FSH),estradiol(E2)],the levels of oxidative stress indicators[catalase(CAT),malondialdehyde(MDA),superoxide dismutase(SOD)]were compared before and after treatment of the three groups.Results The total effective rate af⁃ter treatment in the acupuncture and medicine combination group was 92.86%,which was higher than 71.43%and 73.81%in the acu⁃puncture group and Chinese medicine group(P<0.05);the skin lesion color[(1.16±0.38)points vs.(1.57±0.54)points vs.(1.42±0.49)points]and area score[(1.05±0.34)points vs.(1.49±0.50)points vs.(1.38±0.42)points]in the acupuncture and medicine combination group were lower than those in the acupuncture group and the Chinese medicine group after treatment.Skin elasticity and skin moisture content in the acupuncture and medicine combination group were higher than those in the acupuncture group and the Chinese medicine group(P<0.05);serum LH,FSH,E2 and MDA levels in the acupuncture and medicine combination group were lower than those in the acupuncture group and the Chinese medicine group after treatment(P<0.05).Serum CAT[(2.28±0.53)U/mL vs.(1.69±0.47)U/mL vs.(1.85±0.43)U/mL]and SOD levels[(104.48±10.73)U/mL vs.(89.52±8.90)U/mL vs.(93.59±9.26)U/mL]in the acupuncture and medi⁃cine combination group were higher than those in the acupuncture group and the Chinese medicine group,serum MDA level[(3.52±0.64)mmol/mL vs.(4.71±0.75)mmol/L vs.(4.47±0.69)mmol/L]in the acupuncture and medicine combination group was higher than that in the acupuncture group and the Chinese medicine group(P<0.05).Conclusion The application of neck three-needle combined with sihong quban decoction in the treatment of female patients with chloasma with qi stagnation and blood stasis can reduce the body's oxidative stress response,regulate the expression of sex hormones,reduce skin damage,improve skin conditions,and have significant effects.
作者
李艳梅
LI Yanmei(Department of Dermatology,Henan Hongli Hospital,Xinxiang,Henan453400,China)
出处
《安徽医药》
CAS
2022年第4期733-737,共5页
Anhui Medical and Pharmaceutical Journal
关键词
黑变病
皮肤表现
针刺穴位
过氧化氢酶
雌二醇
中草药
颈三针
四红祛斑汤
气滞血瘀型
黄褐斑
氧化应激反应
Melanosis
Skin manifestations
Acupuncture points
Catalase
Estradiol
Drugs,Chinese herbal
Neck three needles
Sihong quban decoction
Qi stagnation and blood stasis type
Chloasma
Oxidative stress response
