摘要
本研究对现有腹泻型肠易激综合征(IBS–D)动物模型各造模方法进行总结,从病理模型(母婴分离模型、束缚应激模型、直结肠扩张模型、多因素联合模型、其他模型)及病证结合模型(肝郁脾虚病证模型、脾肾阳虚病证模型、脾胃湿热病证模型)不同造模方法分析了现有的IBS–D动物模型的造模状况,并比较其各自优缺点,以期对IBS–D的后续病机研究和药物开发等提供参考。
In this study,we summarize the existing animal models of diarrhea irritable bowel syndrome(IBS-D),ranging from pathological model(mother-infant separation model,bound stress model,colorectal distension model,multi-factor joint model and other models)and integrated disease and syndrome model(liver depression and spleen deficiency syndrome model,spleen and kidney yang deficiency syndrome model,spleen and stomach damp heat syndrome model).Different modeling methods were used to analyze the current status of animal models of IBS-D,and their advantages and disadvantages were compared,in order to provide reference for the follow-up pathogenesis research and drug development of IBS-D.
作者
林雨康
陈涛
李幸展
杨梅林
李璟弘
张佳敏
LIN Yu-kang;CHEN Tao;LI Xing-zhan;YANG Mei-lin;LI Jing-hong;ZHANG Jia-min(Hunan University of Chinese Medicine,Hunan Changsha 410208)
出处
《深圳中西医结合杂志》
2022年第1期133-136,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
湖南省大学生创新创业训练计划项目(S202110541025)。
关键词
腹泻型肠易激综合征
动物模型
病理模型
病证结合模型
Diarrhea irritable bowel syndrome
Animal model
Pathological model
Integrated disease and syndrome model
