摘要
目的 探讨甲状腺功能亢进患者血清丝氨酸蛋白酶抑制剂(Vaspin)、血清孤独G蛋白偶联受体配体(Apelin)、血清趋化素(chemerin)水平与骨代谢的关系。方法 将100例甲状腺功能亢进患者按照骨密度分为骨量正常组30例、骨量减少组35例和骨质疏松组35例。比较3组患者的基线资料,血清Vaspin、血清Apelin、血清chemerin水平和骨代谢指标水平,分析血清Vaspin、血清Apelin、血清chemerin水平与骨代谢指标的关系。结果 3组患者性别、年龄和基础疾病情况比较,差异无统计学意义(P>0.05)。3组患者的25-羟基维生素D(25-OH VD)和Ⅰ型前胶原N-末端前肽(PINP)值随着骨密度的减小而减小,骨源性碱性磷酸酶(BALP)、血清骨钙素(BGP)和β-胶原特殊序列(β-CTX)值随着骨密度的减小而增大,差异均有统计学意义(P<0.05)。3组患者血钙(Ca)、血磷(P)水平比较,差异无统计学意义(P>0.05);3组患者血清甲状旁腺激素(PTH)水平、Vaspin、Apelin和chemerin的值随骨密度的下降而升高,差异有统计学意义(P<0.05)。血清Vaspin、Apelin、chemerin表达水平与骨代谢指标均呈正相关(P<0.05)。结论 甲状腺功能亢进患者血清Vaspin、Apelin、chemerin水平变化与骨密度下降有一定的相关性,临床上可结合血清Vaspin、Apelin、chemerin水平来评估甲状腺功能亢进患者骨代谢状况,进而采取措施预防骨质疏松。
Objective To investigate the relationships of levels of serum serine protease inhibitor(Vaspin),ligand of the receptor that belongs to the G protein-coupled receptor family (Apelin),chemokine with bone metabolism in patients with hyperthyroidism.Methods A total of 100 patients with hyperthyroidism were divided into normal bone mass group (30 cases),osteopenia group (35 cases)and osteoporosis group (35 cases) according to bone mineral density.The baseline data,serum Vaspin,serum Apelin,serum chemerin levels and bone metabolism indexes were compared among the three groups,and the relationships of serum Vaspin,serum Apelin,serum chemerin levels with bone metabolism indexes were analyzed.Results There were no significant differences in gender,age and basic diseases among the three groups (P>0.05).The values of 25 hydroxyvitamin D (25-OH VD)and typeⅠprocollagen N-terminal propeptide (PINP) significantly decreased with the decrease of bone mineral density,while bone derived alkaline phosphatase (BALP),serum osteocalcin (BGP)andβ-collagen specific sequence (β-CTX) values significantly increased with the decrease of bone mineral density (P<0.05).There were no significant differences in the levels of blood calcium (Ca)and blood phosphorus (P) among the three groups (P>0.05).The levels of parathyroid hormone(PTH),serum Vaspin,Apelin and chemerin in the three groups significantly increased with the decrease of bone mineral density (P<0.05).The expression levels of serum Vaspin,Apelin and chemerin were positively correlated with bone metabolism indexes (P<0.05).Conclusion The changes of serum Vaspin,Apelin and chemerin levels in patients with hyperthyroidism show certain correlations with the decline of bone mineral density.Clinically,bone metabolism in patients with hyperthyroidism can be evaluated by combined detection of serum Vaspin,Apelin and chemerin levels,and then the relative measures can be performed to prevent osteoporosis.
作者
王小蕊
孟开顺
翁阳
WANG Xiaorui;MENG Kaishun;WENG Yang(University of Sanya,Sanya,Hainan,572022;Department of Geriatrics,Sanya City People′s Hospital in Hainan Province,Sanya,Hainan,572000;Affiliated Hospital of Hainan Medical University,Haikou,Hainan,570000)
出处
《实用临床医药杂志》
CAS
2022年第4期28-32,共5页
Journal of Clinical Medicine in Practice
基金
海南省自然科学基金项目(817328)。
关键词
甲状腺功能亢进
骨密度
丝氨酸蛋白酶抑制剂
孤独G蛋白偶联受体配体
趋化素
骨代谢
脂肪细胞因子
hyperthyroidism
bone mineral density
serine protease inhibitor
ligand of the receptor that belongs to the G protein-coupled receptor family
chemerin
bone metabolism
adipocytokines
