摘要
In a recent study,Folkmann and colleagues1 show that protein nanoclusters at the surface of biomolecular condensates act as Pickering agents stabilizing these emulsions in cells.The accumulating evidence suggests that cytosol represents a complex emulsion where multiple membrane-bound organelles and biomolecular condensates co-exist together.2 Each of these condensates is a crucible that can enrich for numerous proteins,RNAs,and even the entire membrane-bound organelles,such as the cluster of synaptic vesicles or the Golgi stacks.The molecules in these condensates remain highly mobile,readily exchange with the surrounding environment and grow/coarsening over time(by coalescence or Ostwald ripening),often towards the round structures to minimize the surface tension.
基金
Open Access funding enabled and organized by Projekt DEAL.
