摘要
目的:研究尤瑞克林联合阿托伐他汀、阿司匹林治疗穿支动脉病变型脑梗死患者的疗效。方法:抽取2019年3月~2020年12月我院78例穿支动脉病变型脑梗死患者,依照治疗方法将其分为对照组(39例)、观察组(39例)。对照组予阿托伐他汀+阿司匹林治疗,观察组予阿托伐他汀+阿司匹林+尤瑞克林治疗。两组均连续治疗2周。比较两组临床疗效、血清炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-8(IL-8)、IL-6、超敏C反应蛋白(hs-CRP)]、尿酸(UA)、神经元特异性烯醇化酶(NSE)、血清同型半胱氨酸(Hcy)及神经功能缺损评分。结果:观察组治疗总有效率97.44%高于对照组74.36%,差异具有统计学意义(P<0.05);治疗后观察组IL-8、IL-6、TNF-α、hs-CRP水平低于对照组,差异具有统计学意义(P<0.05);治疗后观察组UA、NSE、Hcy水平低于对照组,差异具有统计学意义(P<0.05);治疗后观察组神经功能缺损评分低于对照组,差异具有统计学意义(P<0.05)。结论:尤瑞克林联合阿托伐他汀、阿司匹林治疗穿支动脉病变型脑梗死患者疗效确切,可降低患者炎性反应,改善神经功能,减轻神经损伤。
Objective:To study the efficacy of Ureklin combined with atorvastatin and aspirin in the treatment of cerebral infarction with perforating artery disease.Methods:A total of 78 patients with cerebral infarction of perforating artery disease in our hospital from March 2019 to December 2020 were selected and divided into a control group(39 cases)and an observation group(39 cases)according to the treatment method.The control group was treated with atorvastatin+aspirin,and the observation group was treated with atorvastatin+aspirin+ureclin.Both groups were treated continuously for 2 weeks.The clinical efficacy,serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-8(IL-8),IL-6,high-sensitivity C-reactive protein(hs-CRP)],uric acid(UA),neuron-specific enolase(NSE),serum homocysteine(Hcy)and neurological deficit score were compared between the two groups.Results:The total effective rate of treatment in the observation group was 97.44% higher than that in the control group,74.36%,and the difference was statistically significant(P<0.05);after treatment,the levels of IL-8,IL-6,TNF-α and hs-CRP in the observation group were lower than those in the control group Group,the difference was statistically significant(P<0.05);after treatment,the levels of UA,NSE,and Hcy in the observation group were lower than those of the control group,and the difference was statistically significant(P<0.05);the neurological deficit score of the observation group after treatment was lower than that of the control Group,the difference was statistically significant(P<0.05).Conclusion:Ureklin combined with atorvastatin and aspirin are effective in the treatment of cerebral infarction with perforating arterial disease,can reduce the inflammatory response,improve nerve function,and reduce nerve damage.
作者
刘相玉
贾晨雨
梁彦启
Liu Xiang-yu;Jia Chen-yu;Liang Yan-qi(Department of Neurology,Zhoukou First People's Hospital,Zhoukou 466700,Henan,China)
出处
《四川生理科学杂志》
2022年第1期23-26,共4页
Sichuan Journal of Physiological Sciences
