摘要
目的探讨α硫辛酸联合莫沙必利对糖尿病性胃轻瘫(DGP)患者氧化应激及肠道菌群的影响。方法选择2019年1月—2020年2月本院收治的84例DGP患者,采用随机双盲法分为2组,各42例。在控制饮食及血糖基础上,观察组采用α硫辛酸+莫沙必利治疗,对照组单用莫沙必利治疗,均持续治疗3周。比较两组血清中氧化应激指标[谷胱甘肽过氧化物酶(GSH-Px)、超氧化物歧化酶(SOD)、活性氧(ROS)]和粪便中肠道菌群(乳酸杆菌、双歧杆菌、肠球菌、肠杆菌)菌落形成单位对数值(lgCFU/g)。结果治疗3周后,观察组GSH-Px、SOD水平为:(28.24±2.83)umoL/L、(275.38±27.54)IU/m,均高于治疗前的(23.37±2.34)umoL/L、(219.57±19.88)IU/m(t=8.612、10.648,P值均<0.05),ROS为(587.41±60.11)IU/m低于治疗前的(660.15±68.02)IU/m,对照组治疗3周后GSHPx、SOD水平为:(25.49±2.66)umoL/L、(248.91±25.97)IU/m,均低于观察组(t=4.589、4.532,P值均<0.05),ROS为(623.24±65.38)IU/m,高于观察组(t=2.615,P<0.05);治疗3周后,观察组乳酸杆菌、双歧杆菌为(8.36±0.45)、(8.98±0.42)lgCFU/g,均高于治疗前的(7.04±0.23)、(8.35±0.31)lgCFU/g,(t=16.927、7.821,P值均<0.05),肠球菌、肠杆菌为(7.65±0.12)、(6.32±0.10)lgCFU/g,低于治疗前的(8.24±0.27)、(6.83±0.26),(t=12.941、11.865,P值均<0.05),对照组治疗后乳酸杆菌、双歧杆菌为(8.11±0.34)、(8.79±0.38)lgCFU/g,均低于观察组(t=2.873、2.174,P值均<0.05),肠球菌、肠杆菌为(7.99±0.18)、(6.61±0.17)lgCFU/g,均高于观察组(t=10.186、9.529,P值均<0.05)。结论采用α硫辛酸联合莫沙必利治疗DGP患者,可有效降低氧化应激反应,调节肠道菌群紊乱,值得推广。
Objective To investigate the effect of α-lipoic acid combined with mosapride on oxidative stress and intestinal flora in patients with diabetic gastroparesis(DGP).Methods A total of 84 DGP patients admitted to our hospital from January 2019 to February 2020 were selected and divided into an observation group and a control group by the random double-blind method,with 42 cases in each group.On the basis of diet and blood sugar control,the observation group was treated with α-lipoic acid combined with mosapride,and the control group was treated with mosapride alone,and the treatment lasted for 3 weeks.The oxidative stress indicators [glutathione peroxidase(GSH-Px),superoxide dismutase(SOD),and reactive oxygen species(ROS)] in serum and the colony forming unit logarithm(lgCFU/g) of intestinal flora(Lactobacillus,Bifidobacterium,Enterococcus and Enterobacter) in feces were compared between the two groups.Results After 3 weeks of the treatment,the levels of GSH PX and SOD in the observation group were:(28.24 ± 2.83) umol/L and(275.38 ± 27.54) IU/m,which were higher than those before the treatment:(23.37 ± 2.34) umol/L and(219.57 ± 19.88) IU/M respectively(t = 8.612,10.648,both P < 0.05),ROS was(587.41 ± 60.11) IU/m,which was lower than that before the treatment:(660.15 ± 68.02) IU/m,and the levels of GSH PX and SOD in the control group were(25.49 ± 2.66) umol/L and(248.91 ± 25.97) IU/m,lower than those in the observation group(t = 4.589,4.532,both P < 0.05),ROS was(623.24 ± 65.38) IU/m,higher than that in the observation group(t = 2.615,P < 0.05).After 3 weeks of the treatment,Lactobacillus and Bifidobacterium in the observation group were(8.36 ± 0.45) lgCFU/g and(8.98 ± 0.42) lgCFU/g,higher than those before the treatment:(7.04 ± 0.23) lgCFU/g and(8.35 ± 0.31) lgCFU/g,(t = 16.927,7.821,both P < 0.05),Enterococcus and Enterobacter were(7.65 ± 0.12) lgCFU/g and(6.32 ± 0.10) lgCFU/g,which were lower than those before the treatment:(8.24 ± 0.27) lgCFU/g and(6.83 ± 0.26) lgCFU/g respectively(t = 12.941,11.865,both P < 0.05).and Lactobacillus and Bifidobacterium in the control group were(8.11 ±0.34) lgCFU/g and(8.79 ± 0.38) lgCFU/g,which were lower than those in the observation group after 3 weeks of the treatment(t = 2.873,2.174,P < 0.05),Enterococcus and Enterobacter were(7.99 ± 0.18) lgCFU/g and(6.61 ± 0.17)lgCFU/g,which were higher than those in the observation group(t = 10.186,9.529,both P < 0.05).Conclusion The use ofα-lipoic acid combined with mosapride in the treatment of patients with DGP can effectively reduce the oxidative stress and regulate intestinal flora disorders,which is worthy of promotion.
作者
寇小兵
KOU Xiao-bing(Department of Endocrinology,Xuchang Central Hospital,Xuchang 461000,Henan,China)
出处
《中国校医》
2022年第2期146-148,共3页
Chinese Journal of School Doctor
关键词
糖尿病性胃轻瘫
Α硫辛酸
莫沙必利
氧化应激
肠道菌群
diabetic gastroparesis(DGP)
α-lipoic acid
mosapride
oxidative stress
intestinal flora
