摘要
目的分析盐酸左氧氟沙星滴耳液联合曲安奈德对急性化脓性中耳炎(ASOM)患者病原菌清除率及听力水平的影响。方法选取2020年4月-2021年4月天津市蓟州区人民医院耳鼻喉科收治的72例ASOM患者,采用随机数字表法进行分为对照组与观察组,各36例。对照组给予盐酸左氧氟沙星滴耳液治疗,观察组在其基础上联合曲安奈德治疗。比较两组症状消失时间、听力阈值、血清炎性因子指标[肿瘤坏死因子-α(TNF-α)、白细胞介素-2(IL-2)、白细胞介素-8(IL-8)]及病原菌清除率。结果观察组症状消失时间短于对照组,差异有统计学意义(P<0.05);两组听力阈值及TNF-α、IL-2、IL-8水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);观察组病原菌清除率为94.44%,高于对照组的77.78%,差异有统计学意义(P<0.05)。结论盐酸左氧氟沙星滴耳液联合曲安奈德可促进ASOM症状的消退,降低体内炎性指标,改善患者听力水平,提升病原菌清除效果。
Objective To analyze the effect of levofloxacin hydrochloride ear drops combined with triamcinolone acetonide on pathogenic bacteria clearance rate and hearing level in patients with acute suppurative otitis media(ASOM).Methods A total of 72 patients with ASOM admitted to Department of Otolaryngology,Tianjin Jizhou District People's Hospital from April 2020 to April 2021 were selected and randomly divided into control group and observation group,with 36 cases in each group.The control group was treated with levofloxacin hydrochloride ear drops,and the observation group was treated with triamcinolone acetonide on the basis of the control group.Symptom disappearance time,hearing threshold,serum inflammatory factors[tumor necrosis factor-α(TNF-α),interleukin-2(IL-2),interleukin-8(IL-8)]and pathogen clearance rate were compared between the two groups.Results The disappearance time of symptoms in the observation group was shorter than that in the control group,and the difference was statistically significant(P<0.05).The hearing threshold and the levels of TNF-α,IL-2 and IL-8 in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.05).The pathogenic bacteria clearance rate of the observation group was 94.44%,which was higher than 77.78%of the control group,and the difference was statistically significant(P<0.05).Conclusion Levofloxacin hydrochloride ear drops combined with triamcinolone acetonide can promote the regression of ASOM symptoms,reduce the inflammatory indexes in vivo,and improve the hearing level and pathogen clearance effect of patients.
作者
刘佳辉
LIU Jia-hui(Department of Otolaryngology,Jizhou District People's Hospital,Tianjin 301900,China)
出处
《医学信息》
2022年第6期156-158,共3页
Journal of Medical Information
关键词
急性化脓性中耳炎
曲安奈德
盐酸左氧氟沙星滴耳液
病原菌
听力阈值
Acute suppurative otitis media
Triamcinolone acetonide
Levofloxacin hydrochloride ear drops
Pathogens
Hearing threshold
