摘要
目的研究阿奇霉素联合头孢地嗪对急性细菌性痢疾(BD)患儿白细胞计数(WBC)及C-反应蛋白水平(CRP)的影响。方法选取2020年5月-2021年5月佳木斯市中心医院儿科收治的82例急性BD患儿,按照随机数字表法分为对照组与观察组,各41例。两组均给予常规对症治疗,在此基础上对照组采用阿奇霉素治疗,观察组采用阿奇霉素联合头孢地嗪治疗,比较两组治疗效果、症状恢复时间、免疫功能指标、WBC及CRP水平、不良反应。结果观察组治疗有效率为87.80%,高于对照组的70.73%,差异有统计学意义(P<0.05);观察组各项症状恢复时间均短于对照组(P<0.05);两组CD3+、CD4+水平高于治疗前,且观察组高于对照组,而CD8+低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组WBC、CRP水平低于治疗前,且观察组低于对照组(P<0.05);观察组与对照组的不良反应发生率分别为14.63%、9.76%,差异无统计学意义(P>0.05)。结论阿奇霉素联合头孢地嗪治疗急性BD效果显著,可缩短患儿症状改善时间,缓解炎性反应,同时促进机体免疫功能的恢复,且不良反应少。
Objective To study the effect of azithromycin combined with cefodizime on white blood cell count(WBC)and C-reactive protein(CRP)in children with acute bacillary dysentery(BD).Methods A total of 82 children with acute BD admitted to Jiamusi Central Hospital from May 2020 to May 2021 were selected and randomly divided into control group and observation group,with 41 cases in each group.Both groups were given conventional symptomatic treatment.On this basis,the control group was treated with azithromycin,and the observation group was treated with azithromycin combined with cefodizime.The therapeutic effect,symptom recovery time,immune function indexes,WBC and CRP levels,and adverse reactions were compared between the two groups.Results The effective rate of the observation group was 87.80%,which was higher than 70.73%of the control group,and the difference was statistically significant(P<0.05).The recovery time of each symptom in the observation group was shorter than that in the control group(P<0.05).After treatment,the levels of CD3+and CD4+in the two groups were higher than those before treatment,and the observation group was higher than the control group,while CD8+was lower than that before treatment,and the observation group was lower than the control group,the difference was statistically significant(P<0.05).After treatment,the levels of WBC and CRP in the two groups were lower than those before treatment,and those in the observation group were lower than the control group(P<0.05).The incidence of adverse reactions in the observation group and the control group was 14.63%and 9.76%,respectively,and the difference was not statistically significant(P>0.05).Conclusion Azithromycin combined with cefodizime is effective in the treatment of acute BD,which can shorten the time of symptom improvement,alleviate inflammatory reaction,and promote the recovery of immune function,with less adverse reactions.
作者
张舒扬
ZHANG Shu-yang(Department of Pediatrics,Jiamusi Central Hospital,Jiamusi 154000,Heilongjiang,China)
出处
《医学信息》
2022年第6期165-167,共3页
Journal of Medical Information
