摘要
目的探讨阻塞性睡眠呼吸暂停低通气综合征患者认知功能损害与血清丙二醛、内皮素-1及淀粉样蛋白A水平的相关性。方法检测130例阻塞性睡眠呼吸暂停低通气综合征患者(观察组)和60名健康志愿者(对照组)的血清丙二醛、内皮素-1、淀粉样蛋白A水平,采用蒙特利尔认知评估量表评定观察组患者的认知功能状况。比较两组间及观察组不同疾病严重程度患者的血清丙二醛、内皮素-1及淀粉样蛋白A水平,采用Pearson相关分析或Spearman秩相关分析探讨丙二醛、内皮素-1、淀粉样蛋白A水平与患者认知功能损害的相关性;绘制受试者工作特征曲线评估丙二醛、内皮素-1、淀粉样蛋白A水平对患者认知功能损害的预测价值。结果观察组血清丙二醛、内皮素-1、淀粉样蛋白A水平显著高于对照组(P<0.05)。不同病情严重程度患者血清丙二醛、内皮素-1、淀粉样蛋白A水平及认知功能障碍发生率比较差异有统计学意义(P<0.05),其中重度患者显著高于轻度、中度患者(P<0.05),中度患者显著高于轻度患者(P<0.05)。伴认知功能障碍患者血清丙二醛、内皮素-1、淀粉样蛋白A水平显著高于不伴认知功能障碍患者(P<0.05)。阻塞性睡眠呼吸暂停低通气综合征患者血清丙二醛、内皮素-1、淀粉样蛋白A水平与蒙特利尔认知评估量表评分呈显著负相关(P<0.05),病情严重程度与认知功能障碍发生率呈显著正相关(P<0.05);受试者工作特征曲线显示,血清丙二醛、内皮素-1、淀粉样蛋白A水平预测认知功能障碍的曲线下面积分别为0.694、0.763、0.719(P<0.05)。结论阻塞性睡眠呼吸暂停低通气综合征患者血清丙二醛、内皮素-1、淀粉样蛋白A水平明显升高,与病情严重程度及认知功能损害相关,在预测认知功能障碍中有一定应用价值。
Objective To investigate the relationship between cognitive impairment and serum malondialdehyde(MDA),endothelin-1(ET-1)and amyloid A protein(SAA)in patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods The levels of serum MDA,ET-1 and SAA were measured in 130 patients with OSAHS(observation group)and 60 healthy volunteers(control group).The cognitive function of the patients in the observation group was assessed by Montreal cognitive assessment scale(MoCA).The levels of serum MDA,ET-1 and SAA in patients with different disease severity between the two groups and the observation group were compared.Pearson correlation analysis or Spearman rank correlation analysis was used to explore the correlation between MDA,ET-1 and SAA levels and cognitive impairment.The receiver operating characteristic curve(ROC)was used to evaluate the predictive value of MDA,ET-1 and SAA levels in patients with cognitive impairment.Results The levels of serum MDA,ET-1 and SAA in the observation group were significantly higher than those in the control group(P<0.05).There were significant differences in the levels of serum MDA,ET-1 and SAA and the incidence of cognitive impairment in patients with different disease severity(P<0.05).Severe patients were significantly higher than mild and moderate patients(P<0.05),and moderate patients were significantly higher than mild patients(P<0.05).The serum levels of MDA,ET-1 and SAA in patients with cognitive impairment were significantly higher than those without cognitive impairment(P<0.05).Serum levels of MDA,ET-1 and SAA in OSAHS patients were significantly negatively correlated with MoCA score(P<0.05),and the condition was significantly positively correlated with cognitive dysfunction(P<0.05).The area under ROC curve of serum MDA,ET-and SAA predicting OSAHS patients with cognitive impairment were 0.694,0.763 and 0.719(P<0.05).Conclusions The serum levels of MDA,ET-1 and SAA in OSAHS patients are significantly increased,which are related to the severity of the disease and cognitive impairment,and has certain application value in predicting cognitive impairment.
作者
张静
张华
王亚静
张鹏
赵兰兰
韩方方
韩迎东
Zhang Jing;Zhang Hua;Wang Yajing;Zhang Peng;Zhao Lanlan;Han Fangfang;Han Yingdong(Zhengzhou Central Hospital Affiliated to Zhengzhou University,Zhengzhou 450007,Henan,China)
出处
《临床心身疾病杂志》
CAS
2022年第2期1-5,共5页
Journal of Clinical Psychosomatic Diseases
基金
河南省医学科技攻关计划联合共建项目(编号2018020776)。
